MGMT expression and pituitary tumours: relationship to tumour biology

Over the past half decade, temozolomide, an oral akylating chemotherapeutic agent, has been shown to have significant activity in the management of aggressive pituitary tumours. The expression of 06-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is an important predictor of respons...

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Veröffentlicht in:	Pituitary 2013-06, Vol.16 (2), p.208-219
Hauptverfasser:	McCormack, Ann, Kaplan, Warren, Gill, Anthony J., Little, Nicholas, Cook, Raymond, Robinson, Bruce, Clifton-Bligh, Roderick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Endocrinology Female Human Physiology Humans Male Medicine Medicine & Public Health Middle Aged Pituitary Neoplasms - drug therapy Pituitary Neoplasms - enzymology Pituitary Neoplasms - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Young Adult
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