Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associ...

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Veröffentlicht in:	Journal of investigative dermatology 2013-06, Vol.133 (6), p.1489-1496
Hauptverfasser:	Heilmann, Stefanie, Kiefer, Amy K., Fricker, Nadine, Drichel, Dmitriy, Hillmer, Axel M., Herold, Christine, Tung, Joyce Y., Eriksson, Nicholas, Redler, Silke, Betz, Regina C., Li, Rui, Kárason, Ari, Nyholt, Dale R., Song, Kijoung, Vermeulen, Sita H., Kanoni, Stavroula, Dedoussis, George, Martin, Nicholas G., Kiemeney, Lambertus A., Mooser, Vincent, Stefansson, Kari, Brent Richards, J., Becker, Tim, Brockschmidt, Felix F., Hinds, David A., Nöthen, Markus M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alopecia Alopecia - epidemiology Alopecia - etiology Alopecia - genetics Alopecia - metabolism Cholestanetriol 26-Monooxygenase - genetics Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 5 European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Frizzled Receptors - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genome-Wide Association Study Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Risk Factors Wnt Proteins - genetics Wnt Signaling Pathway - physiology Wnt3 Protein - genetics
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