Protection against peroxynitrite-induced DNA damage by mesalamine: implications for anti-inflammation and anti-cancer activity

Mesalamine (5-aminosalicylic acid, 5-ASA) is known to be the first-line medication for treatment of patients with ulcerative colitis. Studies have demonstrated that ulcerative colitis patients treated with 5-ASA have an overall decrease in the risk of developing colorectal carcinoma. However, the me...

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Veröffentlicht in:	Molecular and cellular biochemistry 2013-06, Vol.378 (1-2), p.291-298
Hauptverfasser:	Graham, Paul M., Li, Jason Z., Dou, Xueging, Zhu, Hong, Misra, Hara P., Jia, Zhenquan, Li, Yunbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Anti-Inflammatory Agents - chemistry Anticarcinogenic Agents - chemistry Antifungal agents Bacteriophage phi X 174 - genetics Biochemistry Biomedical and Life Sciences Cancer Cardiology Care and treatment Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Colorectal cancer Colorectal Neoplasms - etiology Colorectal Neoplasms - prevention & control Development and progression DNA DNA Breaks, Double-Stranded DNA Breaks, Single-Stranded DNA damage DNA, Viral - genetics Electron Spin Resonance Spectroscopy Free Radical Scavengers - chemistry Free Radicals - chemistry Genetic aspects Genetic research Humans Inflammation Life Sciences Luminol Medical Biochemistry Mesalamine Mesalamine - chemistry Oncology Oxidation-Reduction Oxygen - chemistry Peroxynitrous Acid - chemistry Plasmids - genetics Toy industry Ulcerative colitis
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