Metabolic activation of sulfur mustard leads to oxygen free radical formation

We recently published electron paramagnetic resonance (EPR) spin trapping results that demonstrated the enzymatic reduction of sulfur mustard sulfonium ions to carbon-based free radicals using an in vitro system containing sulfur mustard, cytochrome P450 reductase, NADPH, and the spin trap α-(4-pyri...

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Veröffentlicht in:	Free radical biology & medicine 2012-02, Vol.52 (4), p.811-817
Hauptverfasser:	Brimfield, A.A., Soni, S.D., Trimmer, K.A., Zottola, M.A., Sweeney, R.E., Graham, J.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	carbon catalase cytochrome P-450 electron paramagnetic resonance spectroscopy Electron Spin Resonance Spectroscopy Free radical Humans hydroxyl radicals ions Kinetics Mechanism Models, Chemical Mustard Gas - chemistry NADP (coenzyme) NADP - chemistry NADPH-Ferrihemoprotein Reductase - chemistry Oxidation-Reduction oxygen Oxygen - chemistry paraquat Polypropylenes - chemistry Pyridines - chemistry Reactive oxygen species Reactive Oxygen Species - chemistry Redox cycling Spin Labels sulfur Sulfur mustard superoxide dismutase
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