Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a secreted protease. Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity. However, t...
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| Veröffentlicht in: | Domestic animal endocrinology 2013-07, Vol.45 (1), p.43-48 |
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| creator | Mishra, B. Koshi, K. Kizaki, K. Ushizawa, K. Takahashi, T. Hosoe, M. Sato, T. Ito, A. Hashizume, K. |
| description | A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a secreted protease. Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity. However, the expression and possible role of ADAMTS1 in bovine endometrium is unknown. In this study, we analyzed ADAMTS1 mRNA expression in bovine endometrium during the estrous cycle, peri-implantation period, and at different stages of gestation by using quantitative real-time RT-PCR (qPCR) and in situ hybridization. The qPCR results indicated that the expression of ADAMTS1 mRNA was not affected by the day of the estrous cycle and was similar to cyclic levels on day 35 of gestation; however, the expression was more abundant in cotyledonary tissues of the placenta during late gestation. The in situ hybridization study showed that ADAMTS1 mRNA was detected mainly in uterine luminal epithelia and stromal cells during the estrous cycle and peri-implantation period. A disintegrin and metalloproteinase with thrombospondin motifs 1 mRNA was also expressed in the peri-implantation conceptus as well as in trophoblast cells, which include binucleate cells, and increased during late gestation. Furthermore, treatment of stromal cell with progesterone (300 nM) stimulated the expression of ADAMTS1 mRNA. This study indicates that ADAMTS1 participates in bovine endometrial remodeling, which is required for implantation and placental development in coordination with ovarian steroids. |
| doi_str_mv | 10.1016/j.domaniend.2013.04.002 |
| format | Article |
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Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity. However, the expression and possible role of ADAMTS1 in bovine endometrium is unknown. In this study, we analyzed ADAMTS1 mRNA expression in bovine endometrium during the estrous cycle, peri-implantation period, and at different stages of gestation by using quantitative real-time RT-PCR (qPCR) and in situ hybridization. The qPCR results indicated that the expression of ADAMTS1 mRNA was not affected by the day of the estrous cycle and was similar to cyclic levels on day 35 of gestation; however, the expression was more abundant in cotyledonary tissues of the placenta during late gestation. The in situ hybridization study showed that ADAMTS1 mRNA was detected mainly in uterine luminal epithelia and stromal cells during the estrous cycle and peri-implantation period. A disintegrin and metalloproteinase with thrombospondin motifs 1 mRNA was also expressed in the peri-implantation conceptus as well as in trophoblast cells, which include binucleate cells, and increased during late gestation. Furthermore, treatment of stromal cell with progesterone (300 nM) stimulated the expression of ADAMTS1 mRNA. This study indicates that ADAMTS1 participates in bovine endometrial remodeling, which is required for implantation and placental development in coordination with ovarian steroids.</description><identifier>ISSN: 0739-7240</identifier><identifier>EISSN: 1879-0054</identifier><identifier>DOI: 10.1016/j.domaniend.2013.04.002</identifier><identifier>PMID: 23751571</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ADAM Proteins - genetics ; ADAMTS-1 ; animal ovaries ; Animals ; Bovine ; cattle ; Cattle - metabolism ; conceptus ; Embryo Implantation ; Endometrium ; Endometrium - chemistry ; Estradiol - pharmacology ; estrous cycle ; Estrous Cycle - metabolism ; extracellular matrix ; Female ; gene expression ; Gene Expression - drug effects ; Gestational Age ; in situ hybridization ; Matrix ; messenger RNA ; ovulation ; Placenta ; Placenta - chemistry ; Pregnancy ; progesterone ; Progesterone - pharmacology ; proteinases ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; RNA, Messenger - analysis ; steroids ; stromal cells ; Stromal Cells - drug effects ; Stromal Cells - metabolism ; trophoblast ; Trophoblasts - chemistry</subject><ispartof>Domestic animal endocrinology, 2013-07, Vol.45 (1), p.43-48</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-2ef04b3116efeafaf41f500c35a85f3da29dae87409ef9709ca656783e1cd34f3</citedby><cites>FETCH-LOGICAL-c461t-2ef04b3116efeafaf41f500c35a85f3da29dae87409ef9709ca656783e1cd34f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.domaniend.2013.04.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23751571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishra, B.</creatorcontrib><creatorcontrib>Koshi, K.</creatorcontrib><creatorcontrib>Kizaki, K.</creatorcontrib><creatorcontrib>Ushizawa, K.</creatorcontrib><creatorcontrib>Takahashi, T.</creatorcontrib><creatorcontrib>Hosoe, M.</creatorcontrib><creatorcontrib>Sato, T.</creatorcontrib><creatorcontrib>Ito, A.</creatorcontrib><creatorcontrib>Hashizume, K.</creatorcontrib><title>Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation</title><title>Domestic animal endocrinology</title><addtitle>Domest Anim Endocrinol</addtitle><description>A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a secreted protease. Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity. However, the expression and possible role of ADAMTS1 in bovine endometrium is unknown. In this study, we analyzed ADAMTS1 mRNA expression in bovine endometrium during the estrous cycle, peri-implantation period, and at different stages of gestation by using quantitative real-time RT-PCR (qPCR) and in situ hybridization. The qPCR results indicated that the expression of ADAMTS1 mRNA was not affected by the day of the estrous cycle and was similar to cyclic levels on day 35 of gestation; however, the expression was more abundant in cotyledonary tissues of the placenta during late gestation. The in situ hybridization study showed that ADAMTS1 mRNA was detected mainly in uterine luminal epithelia and stromal cells during the estrous cycle and peri-implantation period. A disintegrin and metalloproteinase with thrombospondin motifs 1 mRNA was also expressed in the peri-implantation conceptus as well as in trophoblast cells, which include binucleate cells, and increased during late gestation. Furthermore, treatment of stromal cell with progesterone (300 nM) stimulated the expression of ADAMTS1 mRNA. This study indicates that ADAMTS1 participates in bovine endometrial remodeling, which is required for implantation and placental development in coordination with ovarian steroids.</description><subject>ADAM Proteins - genetics</subject><subject>ADAMTS-1</subject><subject>animal ovaries</subject><subject>Animals</subject><subject>Bovine</subject><subject>cattle</subject><subject>Cattle - metabolism</subject><subject>conceptus</subject><subject>Embryo Implantation</subject><subject>Endometrium</subject><subject>Endometrium - chemistry</subject><subject>Estradiol - pharmacology</subject><subject>estrous cycle</subject><subject>Estrous Cycle - metabolism</subject><subject>extracellular matrix</subject><subject>Female</subject><subject>gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Gestational Age</subject><subject>in situ hybridization</subject><subject>Matrix</subject><subject>messenger RNA</subject><subject>ovulation</subject><subject>Placenta</subject><subject>Placenta - chemistry</subject><subject>Pregnancy</subject><subject>progesterone</subject><subject>Progesterone - pharmacology</subject><subject>proteinases</subject><subject>quantitative polymerase chain reaction</subject><subject>reverse transcriptase polymerase chain reaction</subject><subject>RNA, Messenger - analysis</subject><subject>steroids</subject><subject>stromal cells</subject><subject>Stromal Cells - drug effects</subject><subject>Stromal Cells - metabolism</subject><subject>trophoblast</subject><subject>Trophoblasts - chemistry</subject><issn>0739-7240</issn><issn>1879-0054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAURi0EokPhL1Av2SRcPxIny6iUh1SKRNu15bGvRx5N7MFOKvj3uJrSLStvzv2OdQi5YNAyYP3HfevSbGLA6FoOTLQgWwD-gmzYoMYGoJMvyQaUGBvFJZyRN6XsAUDV69fkjAvVsU6xDbm5-n3MWEpIkSZPp0_T97tbRuefNxMNkW7TQ4hIqybNuOSwztRER48HYzEuhro1h7ijOyyLWerGW_LKm0PBd0_vObn_fHV3-bW5_vHl2-V03VjZs6Xh6EFuBWM9ejTeeMl8B2BFZ4bOC2f46AwOSsKIflQwWtN3vRoEMuuE9OKcfDjtHnP6tVa7nkOxeDiYiGktmom-HzhnHVRUnVCbUykZvT7mMJv8RzPQjzH1Xj_H1I8xNUhdY9bL90-SdTuje777V68CFyfAm6TNLoei72_rggSoZj72lZhOBNYYDwGzLrZ6LLqQ0S5VHP77jb_dz5KO</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Mishra, B.</creator><creator>Koshi, K.</creator><creator>Kizaki, K.</creator><creator>Ushizawa, K.</creator><creator>Takahashi, T.</creator><creator>Hosoe, M.</creator><creator>Sato, T.</creator><creator>Ito, A.</creator><creator>Hashizume, K.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation</title><author>Mishra, B. ; Koshi, K. ; Kizaki, K. ; Ushizawa, K. ; Takahashi, T. ; Hosoe, M. ; Sato, T. ; Ito, A. ; Hashizume, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-2ef04b3116efeafaf41f500c35a85f3da29dae87409ef9709ca656783e1cd34f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>ADAM Proteins - genetics</topic><topic>ADAMTS-1</topic><topic>animal ovaries</topic><topic>Animals</topic><topic>Bovine</topic><topic>cattle</topic><topic>Cattle - metabolism</topic><topic>conceptus</topic><topic>Embryo Implantation</topic><topic>Endometrium</topic><topic>Endometrium - chemistry</topic><topic>Estradiol - pharmacology</topic><topic>estrous cycle</topic><topic>Estrous Cycle - metabolism</topic><topic>extracellular matrix</topic><topic>Female</topic><topic>gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Gestational Age</topic><topic>in situ hybridization</topic><topic>Matrix</topic><topic>messenger RNA</topic><topic>ovulation</topic><topic>Placenta</topic><topic>Placenta - chemistry</topic><topic>Pregnancy</topic><topic>progesterone</topic><topic>Progesterone - pharmacology</topic><topic>proteinases</topic><topic>quantitative polymerase chain reaction</topic><topic>reverse transcriptase polymerase chain reaction</topic><topic>RNA, Messenger - analysis</topic><topic>steroids</topic><topic>stromal cells</topic><topic>Stromal Cells - drug effects</topic><topic>Stromal Cells - metabolism</topic><topic>trophoblast</topic><topic>Trophoblasts - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, B.</creatorcontrib><creatorcontrib>Koshi, K.</creatorcontrib><creatorcontrib>Kizaki, K.</creatorcontrib><creatorcontrib>Ushizawa, K.</creatorcontrib><creatorcontrib>Takahashi, T.</creatorcontrib><creatorcontrib>Hosoe, M.</creatorcontrib><creatorcontrib>Sato, T.</creatorcontrib><creatorcontrib>Ito, A.</creatorcontrib><creatorcontrib>Hashizume, K.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, B.</au><au>Koshi, K.</au><au>Kizaki, K.</au><au>Ushizawa, K.</au><au>Takahashi, T.</au><au>Hosoe, M.</au><au>Sato, T.</au><au>Ito, A.</au><au>Hashizume, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>45</volume><issue>1</issue><spage>43</spage><epage>48</epage><pages>43-48</pages><issn>0739-7240</issn><eissn>1879-0054</eissn><abstract>A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a secreted protease. Through the regulation of extracellular matrix remodeling or developmental processes or both, ADAMTS1 is involved in several biological functions, including ovulation and embryo receptivity. However, the expression and possible role of ADAMTS1 in bovine endometrium is unknown. In this study, we analyzed ADAMTS1 mRNA expression in bovine endometrium during the estrous cycle, peri-implantation period, and at different stages of gestation by using quantitative real-time RT-PCR (qPCR) and in situ hybridization. The qPCR results indicated that the expression of ADAMTS1 mRNA was not affected by the day of the estrous cycle and was similar to cyclic levels on day 35 of gestation; however, the expression was more abundant in cotyledonary tissues of the placenta during late gestation. The in situ hybridization study showed that ADAMTS1 mRNA was detected mainly in uterine luminal epithelia and stromal cells during the estrous cycle and peri-implantation period. A disintegrin and metalloproteinase with thrombospondin motifs 1 mRNA was also expressed in the peri-implantation conceptus as well as in trophoblast cells, which include binucleate cells, and increased during late gestation. Furthermore, treatment of stromal cell with progesterone (300 nM) stimulated the expression of ADAMTS1 mRNA. This study indicates that ADAMTS1 participates in bovine endometrial remodeling, which is required for implantation and placental development in coordination with ovarian steroids.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23751571</pmid><doi>10.1016/j.domaniend.2013.04.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Domestic animal endocrinology, 2013-07, Vol.45 (1), p.43-48 |
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| subjects | ADAM Proteins - genetics ADAMTS-1 animal ovaries Animals Bovine cattle Cattle - metabolism conceptus Embryo Implantation Endometrium Endometrium - chemistry Estradiol - pharmacology estrous cycle Estrous Cycle - metabolism extracellular matrix Female gene expression Gene Expression - drug effects Gestational Age in situ hybridization Matrix messenger RNA ovulation Placenta Placenta - chemistry Pregnancy progesterone Progesterone - pharmacology proteinases quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction RNA, Messenger - analysis steroids stromal cells Stromal Cells - drug effects Stromal Cells - metabolism trophoblast Trophoblasts - chemistry |
| title | Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation |
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