Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats
Daily administration of xanthohumol (16.9mg/kg) for 6weeks resulted in lower body weight and lower fasting plasma glucose in obese male but not in female Zucker fa/fa rats. [Display omitted] ► Zucker fa/fa rats were treated with xanthohumol from hops for 6weeks. ► Xanthohumol lowered fasting plasma...
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| Veröffentlicht in: | Phytochemistry (Oxford) 2013-07, Vol.91, p.236-241 |
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| creator | Legette, LeeCole L. Moreno Luna, Arlyn Y. Reed, Ralph L. Miranda, Cristobal L. Bobe, Gerd Proteau, Rosita R. Stevens, Jan F. |
| description | Daily administration of xanthohumol (16.9mg/kg) for 6weeks resulted in lower body weight and lower fasting plasma glucose in obese male but not in female Zucker fa/fa rats. [Display omitted]
► Zucker fa/fa rats were treated with xanthohumol from hops for 6weeks. ► Xanthohumol lowered fasting plasma glucose in male animals at a dose of 16.9mg/kg. ► Xanthohumol lowered body weight in male animals at a dose of 16.9mg/kg. ► Steady-state plasma and liver tissue levels of xanthohumol agree with dose–effect relationships.
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9mg/kg BW for 6weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid–chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (p |
| doi_str_mv | 10.1016/j.phytochem.2012.04.018 |
| format | Article |
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► Zucker fa/fa rats were treated with xanthohumol from hops for 6weeks. ► Xanthohumol lowered fasting plasma glucose in male animals at a dose of 16.9mg/kg. ► Xanthohumol lowered body weight in male animals at a dose of 16.9mg/kg. ► Steady-state plasma and liver tissue levels of xanthohumol agree with dose–effect relationships.
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9mg/kg BW for 6weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid–chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (p<0.05) elevated in the highest dose group. There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/j.phytochem.2012.04.018</identifier><identifier>PMID: 22640929</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>animal models ; Animals ; biomarkers ; blood glucose ; Blood Glucose - drug effects ; Cannabaceae ; cardiovascular diseases ; chemokines ; cholesterol ; chronic diseases ; Dose-Response Relationship, Drug ; Eating - drug effects ; Fasting ; Female ; flavonoids ; Flavonoids - blood ; Flavonoids - chemistry ; Flavonoids - pharmacology ; food intake ; glucose ; Hops ; Humulus lupulus ; insulin ; liver ; Male ; Metabolic syndrome ; metabolites ; Molecular Structure ; noninsulin-dependent diabetes mellitus ; Obesity ; Obesity - drug therapy ; Propiophenones - blood ; Propiophenones - chemistry ; Propiophenones - pharmacology ; Rats ; Rats, Zucker ; risk ; tandem mass spectrometry ; triacylglycerols ; Type 2 diabetes ; Weight Loss - drug effects ; Xanthohumol</subject><ispartof>Phytochemistry (Oxford), 2013-07, Vol.91, p.236-241</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-16ca2b0b06803da36da70d983a3052182f1e11c09e7efa1e77aff1eca71985aa3</citedby><cites>FETCH-LOGICAL-c461t-16ca2b0b06803da36da70d983a3052182f1e11c09e7efa1e77aff1eca71985aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031942212002002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22640929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Legette, LeeCole L.</creatorcontrib><creatorcontrib>Moreno Luna, Arlyn Y.</creatorcontrib><creatorcontrib>Reed, Ralph L.</creatorcontrib><creatorcontrib>Miranda, Cristobal L.</creatorcontrib><creatorcontrib>Bobe, Gerd</creatorcontrib><creatorcontrib>Proteau, Rosita R.</creatorcontrib><creatorcontrib>Stevens, Jan F.</creatorcontrib><title>Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Daily administration of xanthohumol (16.9mg/kg) for 6weeks resulted in lower body weight and lower fasting plasma glucose in obese male but not in female Zucker fa/fa rats. [Display omitted]
► Zucker fa/fa rats were treated with xanthohumol from hops for 6weeks. ► Xanthohumol lowered fasting plasma glucose in male animals at a dose of 16.9mg/kg. ► Xanthohumol lowered body weight in male animals at a dose of 16.9mg/kg. ► Steady-state plasma and liver tissue levels of xanthohumol agree with dose–effect relationships.
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9mg/kg BW for 6weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid–chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (p<0.05) elevated in the highest dose group. There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.</description><subject>animal models</subject><subject>Animals</subject><subject>biomarkers</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Cannabaceae</subject><subject>cardiovascular diseases</subject><subject>chemokines</subject><subject>cholesterol</subject><subject>chronic diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - drug effects</subject><subject>Fasting</subject><subject>Female</subject><subject>flavonoids</subject><subject>Flavonoids - blood</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - pharmacology</subject><subject>food intake</subject><subject>glucose</subject><subject>Hops</subject><subject>Humulus lupulus</subject><subject>insulin</subject><subject>liver</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>metabolites</subject><subject>Molecular Structure</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Propiophenones - blood</subject><subject>Propiophenones - chemistry</subject><subject>Propiophenones - pharmacology</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>risk</subject><subject>tandem mass spectrometry</subject><subject>triacylglycerols</subject><subject>Type 2 diabetes</subject><subject>Weight Loss - drug effects</subject><subject>Xanthohumol</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCX6A-ckk6dhI7OVYVX1IlDlCp7cWaOJONlyRe7IRq_z1ebemV04xGz7wzehi7FJALEOpql--Hw-LtQFMuQcgcyhxE_YptRK2LrNAAr9kGoBBZU0p5zt7GuAOAqlLqDTuXUpXQyGbDHu5xXgY_rJMf-eifKETe-u7An8hth4Xj3PEe4-LmLd-PGCfk23G1PhJ3M_ctpWbCkfjjan9RSOxVjzzgEt-xsx7HSO-f6wW7-_zp583X7Pb7l28317eZLZVYMqEsyhZaUDUUHRaqQw1dUxdYQCVFLXtBQlhoSFOPgrTGPo0satHUFWJxwT6ecvfB_14pLmZy0dI44kx-jUYUSlW6UaASqk-oDT7GQL3ZBzdhOBgB5ujV7MyLV3P0aqA0yWva_PB8ZG0n6l72_olMwOUJ6NEb3AYXzd2PlFAdpSvdHCOuTwQlGX8cBROto9lS5wLZxXTe_feNv59Kl5I</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Legette, LeeCole L.</creator><creator>Moreno Luna, Arlyn Y.</creator><creator>Reed, Ralph L.</creator><creator>Miranda, Cristobal L.</creator><creator>Bobe, Gerd</creator><creator>Proteau, Rosita R.</creator><creator>Stevens, Jan F.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats</title><author>Legette, LeeCole L. ; Moreno Luna, Arlyn Y. ; Reed, Ralph L. ; Miranda, Cristobal L. ; Bobe, Gerd ; Proteau, Rosita R. ; Stevens, Jan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-16ca2b0b06803da36da70d983a3052182f1e11c09e7efa1e77aff1eca71985aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>animal models</topic><topic>Animals</topic><topic>biomarkers</topic><topic>blood glucose</topic><topic>Blood Glucose - drug effects</topic><topic>Cannabaceae</topic><topic>cardiovascular diseases</topic><topic>chemokines</topic><topic>cholesterol</topic><topic>chronic diseases</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - drug effects</topic><topic>Fasting</topic><topic>Female</topic><topic>flavonoids</topic><topic>Flavonoids - blood</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - pharmacology</topic><topic>food intake</topic><topic>glucose</topic><topic>Hops</topic><topic>Humulus lupulus</topic><topic>insulin</topic><topic>liver</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>metabolites</topic><topic>Molecular Structure</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Propiophenones - blood</topic><topic>Propiophenones - chemistry</topic><topic>Propiophenones - pharmacology</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>risk</topic><topic>tandem mass spectrometry</topic><topic>triacylglycerols</topic><topic>Type 2 diabetes</topic><topic>Weight Loss - drug effects</topic><topic>Xanthohumol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Legette, LeeCole L.</creatorcontrib><creatorcontrib>Moreno Luna, Arlyn Y.</creatorcontrib><creatorcontrib>Reed, Ralph L.</creatorcontrib><creatorcontrib>Miranda, Cristobal L.</creatorcontrib><creatorcontrib>Bobe, Gerd</creatorcontrib><creatorcontrib>Proteau, Rosita R.</creatorcontrib><creatorcontrib>Stevens, Jan F.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Legette, LeeCole L.</au><au>Moreno Luna, Arlyn Y.</au><au>Reed, Ralph L.</au><au>Miranda, Cristobal L.</au><au>Bobe, Gerd</au><au>Proteau, Rosita R.</au><au>Stevens, Jan F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>91</volume><spage>236</spage><epage>241</epage><pages>236-241</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>Daily administration of xanthohumol (16.9mg/kg) for 6weeks resulted in lower body weight and lower fasting plasma glucose in obese male but not in female Zucker fa/fa rats. [Display omitted]
► Zucker fa/fa rats were treated with xanthohumol from hops for 6weeks. ► Xanthohumol lowered fasting plasma glucose in male animals at a dose of 16.9mg/kg. ► Xanthohumol lowered body weight in male animals at a dose of 16.9mg/kg. ► Steady-state plasma and liver tissue levels of xanthohumol agree with dose–effect relationships.
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9mg/kg BW for 6weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid–chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (p<0.05) elevated in the highest dose group. There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22640929</pmid><doi>10.1016/j.phytochem.2012.04.018</doi><tpages>6</tpages></addata></record> |
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| subjects | animal models Animals biomarkers blood glucose Blood Glucose - drug effects Cannabaceae cardiovascular diseases chemokines cholesterol chronic diseases Dose-Response Relationship, Drug Eating - drug effects Fasting Female flavonoids Flavonoids - blood Flavonoids - chemistry Flavonoids - pharmacology food intake glucose Hops Humulus lupulus insulin liver Male Metabolic syndrome metabolites Molecular Structure noninsulin-dependent diabetes mellitus Obesity Obesity - drug therapy Propiophenones - blood Propiophenones - chemistry Propiophenones - pharmacology Rats Rats, Zucker risk tandem mass spectrometry triacylglycerols Type 2 diabetes Weight Loss - drug effects Xanthohumol |
| title | Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats |
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