Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions
The aim of this study was to determine the salivary concentrations of tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) in patients with premalignant and malignant lesions. The study involved 57 patients who were examined between 2008 and 2010 at the Department of Oral Medicine and Departmen...
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| Veröffentlicht in: | Folia biologica 2013, Vol.59 (2), p.99-102 |
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| container_title | Folia biologica |
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| creator | Juretić, M Cerović, R Belušić-Gobić, M Brekalo Pršo, I Kqiku, L Špalj, S Pezelj-Ribarić, S |
| description | The aim of this study was to determine the salivary concentrations of tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) in patients with premalignant and malignant lesions. The study involved 57 patients who were examined between 2008 and 2010 at the Department of Oral Medicine and Department of Oral and Maxillofacial Surgery of the Medical Faculty, University of Rijeka, Croatia. They were divided into three groups: 19 patients with oral premalignant lesions, 19 with oral squamous cell carcinoma and 19 healthy control volunteers. Whole saliva was collected and investigated for the presence of TNF-α and IL-6 by enzyme immunoassay at the Department of Dentistry and Maxillofacial Surgery, Medical Faculty, University of Graz, Austria. All groups had statistically significant differences in values of TNF-α and IL-6 (P < 0.001). The results suggest that these proinflammatory cytokines are elevated in the saliva of patients with oral squamous cell carcinoma and oral premalignant lesions as compared to controls, which may have diagnostic and/or prognostic significance. |
| doi_str_mv | 10.14712/fb2013059020099 |
| format | Article |
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The study involved 57 patients who were examined between 2008 and 2010 at the Department of Oral Medicine and Department of Oral and Maxillofacial Surgery of the Medical Faculty, University of Rijeka, Croatia. They were divided into three groups: 19 patients with oral premalignant lesions, 19 with oral squamous cell carcinoma and 19 healthy control volunteers. Whole saliva was collected and investigated for the presence of TNF-α and IL-6 by enzyme immunoassay at the Department of Dentistry and Maxillofacial Surgery, Medical Faculty, University of Graz, Austria. All groups had statistically significant differences in values of TNF-α and IL-6 (P < 0.001). The results suggest that these proinflammatory cytokines are elevated in the saliva of patients with oral squamous cell carcinoma and oral premalignant lesions as compared to controls, which may have diagnostic and/or prognostic significance.</description><subject>Adult</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Case-Control Studies</subject><subject>Demography</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - metabolism</subject><subject>Lichen Planus, Oral - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Precancerous Conditions - metabolism</subject><subject>Saliva - metabolism</subject><subject>Smoking - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0015-5500</issn><issn>2533-7602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1OwzAQhC0EoqVw54R85BJYe2O7PqKKQqUKDpQTh8hJbAhyfoiTIh6LF-GZiNoCEqfVar8Z7QwhpwwuWKwYv3QpB4YgNHAArffImAvESEng-2QMwEQkBMCIHIXwCoAxIB6SEUcVS6bkmDw9GF-sTftBvV1bH2jt6OpuHn19UlPldLGMJC0q2piusFUX6HvRvdC6NZ42rS0H7XNlqm7D_m3ehqKuwjE5cMYHe7KbE_I4v17NbqPl_c1idrWMMi54FymldKZ4zs10eIlp45iWKkdM0cSxySVqpnnuwKEUHC2Ph4MCZ5HDNMUYJ-R869u09VtvQ5eURcis96aydR8ShlIKpVHJAYUtmrV1CK11SdMW5RA_YZBsKk3-VTpIznbufVra_Ffw0yF-AyQlcFE</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Juretić, M</creator><creator>Cerović, R</creator><creator>Belušić-Gobić, M</creator><creator>Brekalo Pršo, I</creator><creator>Kqiku, L</creator><creator>Špalj, S</creator><creator>Pezelj-Ribarić, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions</title><author>Juretić, M ; Cerović, R ; Belušić-Gobić, M ; Brekalo Pršo, I ; Kqiku, L ; Špalj, S ; Pezelj-Ribarić, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-7779c72d2a817619af1967d33b3a44ad639192df0f36523e24b3a70fe3208b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Case-Control Studies</topic><topic>Demography</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - metabolism</topic><topic>Lichen Planus, Oral - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Precancerous Conditions - metabolism</topic><topic>Saliva - metabolism</topic><topic>Smoking - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juretić, M</creatorcontrib><creatorcontrib>Cerović, R</creatorcontrib><creatorcontrib>Belušić-Gobić, M</creatorcontrib><creatorcontrib>Brekalo Pršo, I</creatorcontrib><creatorcontrib>Kqiku, L</creatorcontrib><creatorcontrib>Špalj, S</creatorcontrib><creatorcontrib>Pezelj-Ribarić, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Folia biologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juretić, M</au><au>Cerović, R</au><au>Belušić-Gobić, M</au><au>Brekalo Pršo, I</au><au>Kqiku, L</au><au>Špalj, S</au><au>Pezelj-Ribarić, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions</atitle><jtitle>Folia biologica</jtitle><addtitle>Folia Biol (Praha)</addtitle><date>2013</date><risdate>2013</risdate><volume>59</volume><issue>2</issue><spage>99</spage><epage>102</epage><pages>99-102</pages><issn>0015-5500</issn><eissn>2533-7602</eissn><abstract>The aim of this study was to determine the salivary concentrations of tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) in patients with premalignant and malignant lesions. The study involved 57 patients who were examined between 2008 and 2010 at the Department of Oral Medicine and Department of Oral and Maxillofacial Surgery of the Medical Faculty, University of Rijeka, Croatia. They were divided into three groups: 19 patients with oral premalignant lesions, 19 with oral squamous cell carcinoma and 19 healthy control volunteers. Whole saliva was collected and investigated for the presence of TNF-α and IL-6 by enzyme immunoassay at the Department of Dentistry and Maxillofacial Surgery, Medical Faculty, University of Graz, Austria. All groups had statistically significant differences in values of TNF-α and IL-6 (P < 0.001). The results suggest that these proinflammatory cytokines are elevated in the saliva of patients with oral squamous cell carcinoma and oral premalignant lesions as compared to controls, which may have diagnostic and/or prognostic significance.</abstract><cop>Czech Republic</cop><pmid>23746176</pmid><doi>10.14712/fb2013059020099</doi><tpages>4</tpages></addata></record> |
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| ispartof | Folia biologica, 2013, Vol.59 (2), p.99-102 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Carcinoma, Squamous Cell - metabolism Case-Control Studies Demography Female Humans Interleukin-6 - metabolism Lichen Planus, Oral - metabolism Male Middle Aged Mouth Neoplasms - metabolism Precancerous Conditions - metabolism Saliva - metabolism Smoking - metabolism Tumor Necrosis Factor-alpha - metabolism |
| title | Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions |
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