Cinacalcet attenuates hypercalcemia observed in mice bearing either Rice H-500 Leydig cell or C26-DCT colon tumors

Excessive secretion of parathyroid hormone-related protein (PTHrP) by tumors stimulates bone resorption and increases renal tubular reabsorption of calcium, resulting in hypercalcemia of malignancy. We investigated the ability of cinacalcet, an allosteric modulator of the calcium-sensing receptor, t...

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Veröffentlicht in:	European journal of pharmacology 2013-07, Vol.712 (1-3), p.8-15
Hauptverfasser:	Colloton, Matthew, Shatzen, Edward, Wiemann, Bernadette, Starnes, Charlie, Scully, Sheila, Henley, Charles, Martin, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood serum bone resorption Calcimimetic Calcitonin Calcitonin - metabolism Calcium Calcium - blood Calcium - metabolism Cell Line, Tumor Cinacalcet Hydrochloride Colonic Neoplasms - complications Colonic Neoplasms - pathology colorectal neoplasms Female Gene Expression Regulation - drug effects hypercalcemia Hypercalcemia - drug therapy Hypercalcemia - etiology Hypercalcemia - metabolism Hypercalcemia - pathology Leydig Cell Tumor - complications Leydig Cell Tumor - pathology Leydig cells Male messenger RNA Mice Naphthalenes - pharmacology Naphthalenes - therapeutic use Parathyroid hormone-related protein Parathyroid Hormone-Related Protein - genetics Parathyroid Hormone-Related Protein - metabolism pharmacology phosphorus Rats Receptors, Calcium-Sensing - genetics ribonucleases secretion
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