Nasal immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis plus cholera toxin induces protective immunity in aged mice

Previous studies have demonstrated that nasal administration of the outer membrane protein of Porphyromonas gingivalis (40k-OMP) with cholera toxin (CT) as an adjuvant elicits protective immune responses against P. gingivalis in young mice. In the present study, we investigated whether administratio...

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Veröffentlicht in:	Journal of Oral Science 2013, Vol.55(2), pp.107-114
Hauptverfasser:	Cai, Yu, Kurita-Ochiai, Tomoko, Kobayashi, Ryoki, Hashizume, Tomomi, Yamamoto, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Intranasal Age Factors Animals Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Bacterial Outer Membrane Proteins - administration & dosage Bacterial Outer Membrane Proteins - immunology Bacteroidaceae Infections - immunology CD4-Positive T-Lymphocytes - immunology cholera toxin Cholera Toxin - administration & dosage Cholera Toxin - immunology Dentistry Female Immunity, Mucosal - immunology Immunization - methods Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin G - immunology Interferon-gamma - immunology Interleukin-4 - immunology Interleukin-5 - immunology Interleukin-6 - immunology Mice Mice, Inbred BALB C nasal immunization Nasal Mucosa - immunology outer membrane protein Porphyromonas gingivalis Porphyromonas gingivalis - immunology Saliva - immunology T helper cells Th1 Cells - immunology Th2 Cells - immunology
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