Heterogeneity of brain benzodiazepine receptors demonstrated by ( super(3)H)propyl beta -carboline-3-carboxylate binding

Heterogeneity of brain benzodiazepine receptors demonstrated by ( super(3)H)propyl beta -carboline-3-carboxylate binding

( super(3)H)Propyl beta -carboline-3-carboxylate (PrCC) was used as a ligand for in vitro binding studies of the mouse brain benzodiazepine receptor. The data suggest that the benzodiazepine receptor is heterogeneous and that one of its subsets has specificity for beta -carbolines. Several models ar...

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Veröffentlicht in:Molecular pharmacology 1982-01, Vol.21 (3), p.618-628
Hauptverfasser: Hirsch, J D, Kochman, R L, Sumner, PR
Format: Artikel
Sprache:eng
Schlagworte:
benzodiazepines
brain
mice
propyl beta -carboline-3-carboxylate
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Zusammenfassung:( super(3)H)Propyl beta -carboline-3-carboxylate (PrCC) was used as a ligand for in vitro binding studies of the mouse brain benzodiazepine receptor. The data suggest that the benzodiazepine receptor is heterogeneous and that one of its subsets has specificity for beta -carbolines. Several models are proposed for the heterogeneous benzodiazepine receptor that are consistent with this hypothesis.
ISSN:0026-895X