Metal-Free [2 + 2 + 1] Annulation of Alkynes, Nitriles, and Oxygen Atoms: Iodine(III)-Mediated Synthesis of Highly Substituted Oxazoles

The metal-free [2 + 2 + 1] annulation of alkynes, nitriles, and O-atoms for the regioselective assembly of 2,4-disubstituted and 2,4,5-trisubstituted oxazole compounds has been achieved by the use of PhIO with TfOH or Tf2NH. The present reaction could be applied to a facile synthesis of an anti-infl...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic letters 2013-06, Vol.15 (11), p.2672-2675
Hauptverfasser:	Saito, Akio, Taniguchi, Akihiro, Kambara, Yui, Hanzawa, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Catalysis Iodine - chemistry Metals - chemistry Molecular Structure Nitriles - chemistry Oxazoles - chemical synthesis Oxygen - chemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!