Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC-UV-Densitometric Method
A specific and reliable high-performance thin layer chromatography method with densitometry detection has been developed for the determination of naphazoline nitrate in nasal drops. The best separation of the basic analyte, without spot tailing, was achieved by using a mobile phase composed of aceto...
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| Veröffentlicht in: | Journal of chromatographic science 2013-07, Vol.51 (6), p.560-565 |
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| container_title | Journal of chromatographic science |
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| creator | Marszałł, Michał Piotr Sroka, Wiktor Dariusz Balinowska, Aleksandra Mieszkowski, Dominik Koba, Marcin Kaliszan, Roman |
| description | A specific and reliable high-performance thin layer chromatography method with densitometry detection has been developed for the determination of naphazoline nitrate in nasal drops. The best separation of the basic analyte, without spot tailing, was achieved by using a mobile phase composed of acetonitrile-water (60:40, v/v), adding 1.5 % (v/v) imidazolium-class ionic liquid and covering the plates with a stationary phase based on RP-18 with F254S (10 × 20 cm). The presented results confirm that imidazolium tetrafluoroborate ionic liquids are efficient suppressors of free silanols, which are considered to be responsible for troublesome and irreproducible chromatographic determinations of basic compounds. The developed chromatographic system was found to be convenient in use and to provide a repeatable assay of naphazoline nitrate in nasal drops, which could not be obtained with the use of standard silanol suppressing mobile phase additives such as triethylamine or dimethyloctylamine. |
| doi_str_mv | 10.1093/chromsci/bms168 |
| format | Article |
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The best separation of the basic analyte, without spot tailing, was achieved by using a mobile phase composed of acetonitrile-water (60:40, v/v), adding 1.5 % (v/v) imidazolium-class ionic liquid and covering the plates with a stationary phase based on RP-18 with F254S (10 × 20 cm). The presented results confirm that imidazolium tetrafluoroborate ionic liquids are efficient suppressors of free silanols, which are considered to be responsible for troublesome and irreproducible chromatographic determinations of basic compounds. The developed chromatographic system was found to be convenient in use and to provide a repeatable assay of naphazoline nitrate in nasal drops, which could not be obtained with the use of standard silanol suppressing mobile phase additives such as triethylamine or dimethyloctylamine.</description><identifier>ISSN: 0021-9665</identifier><identifier>EISSN: 1945-239X</identifier><identifier>DOI: 10.1093/chromsci/bms168</identifier><identifier>PMID: 23076785</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Acetonitriles - chemistry ; Chromatography, High Pressure Liquid - methods ; Chromatography, Thin Layer - methods ; Densitometry - methods ; Imidazoles - chemistry ; Ionic Liquids - chemistry ; Naphazoline - analysis ; Naphazoline - chemistry ; Pharmaceutical Solutions - chemistry ; Spectrophotometry, Ultraviolet - methods</subject><ispartof>Journal of chromatographic science, 2013-07, Vol.51 (6), p.560-565</ispartof><rights>The Author [2012]. 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The developed chromatographic system was found to be convenient in use and to provide a repeatable assay of naphazoline nitrate in nasal drops, which could not be obtained with the use of standard silanol suppressing mobile phase additives such as triethylamine or dimethyloctylamine.</description><subject>Acetonitriles - chemistry</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Thin Layer - methods</subject><subject>Densitometry - methods</subject><subject>Imidazoles - chemistry</subject><subject>Ionic Liquids - chemistry</subject><subject>Naphazoline - analysis</subject><subject>Naphazoline - chemistry</subject><subject>Pharmaceutical Solutions - chemistry</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><issn>0021-9665</issn><issn>1945-239X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQhS0EglKY2ZBHhBRqx0kcj1WhgNRCh4LYIsd2FKMkDr4EqfwCfjapSllZ7nS6797TPYQuKLmhRLCJKr2rQdlJXgNN0gM0oiKKg5CJt0M0IiSkgUiS-ASdArxvR5rGx-gkZIQnPI1H6PvRNVbhhf3orQYsAS9dbiuDV6UEg6da285-GsCF83huJNh8WE4B5Aa7Aj_JtpRfrrKNwbbZHvlaKtN3VskKz52v-0p21jU43-CH1XoxC15eg1vTgO1cbTo_eC9NVzp9ho4KWYE5_-1j9DK_W88egsXz_eNsuggU46wLpE6ZiIb_wqSIlMhTUyRERYRpQvM44lIWItSRjniYklAUQ-GSaa7TPOFcEzZGVzvd1ruP3kCX1RaUqSrZGNdDRlkSC0Hp4DFGkx2qvAPwpshab2vpNxkl2Tb-bB9_tot_uLj8Fe_z2ug_fp_3AFzvANe3_6r9AFRhk00</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Marszałł, Michał Piotr</creator><creator>Sroka, Wiktor Dariusz</creator><creator>Balinowska, Aleksandra</creator><creator>Mieszkowski, Dominik</creator><creator>Koba, Marcin</creator><creator>Kaliszan, Roman</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC-UV-Densitometric Method</title><author>Marszałł, Michał Piotr ; Sroka, Wiktor Dariusz ; Balinowska, Aleksandra ; Mieszkowski, Dominik ; Koba, Marcin ; Kaliszan, Roman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-ad839423926f4c9b8ef60c403d01b547aaf92d4d4728029f8027a3d7d8b677d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetonitriles - chemistry</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Thin Layer - methods</topic><topic>Densitometry - methods</topic><topic>Imidazoles - chemistry</topic><topic>Ionic Liquids - chemistry</topic><topic>Naphazoline - analysis</topic><topic>Naphazoline - chemistry</topic><topic>Pharmaceutical Solutions - chemistry</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marszałł, Michał Piotr</creatorcontrib><creatorcontrib>Sroka, Wiktor Dariusz</creatorcontrib><creatorcontrib>Balinowska, Aleksandra</creatorcontrib><creatorcontrib>Mieszkowski, Dominik</creatorcontrib><creatorcontrib>Koba, Marcin</creatorcontrib><creatorcontrib>Kaliszan, Roman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatographic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marszałł, Michał Piotr</au><au>Sroka, Wiktor Dariusz</au><au>Balinowska, Aleksandra</au><au>Mieszkowski, Dominik</au><au>Koba, Marcin</au><au>Kaliszan, Roman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC-UV-Densitometric Method</atitle><jtitle>Journal of chromatographic science</jtitle><addtitle>J Chromatogr Sci</addtitle><date>2013-07</date><risdate>2013</risdate><volume>51</volume><issue>6</issue><spage>560</spage><epage>565</epage><pages>560-565</pages><issn>0021-9665</issn><eissn>1945-239X</eissn><abstract>A specific and reliable high-performance thin layer chromatography method with densitometry detection has been developed for the determination of naphazoline nitrate in nasal drops. The best separation of the basic analyte, without spot tailing, was achieved by using a mobile phase composed of acetonitrile-water (60:40, v/v), adding 1.5 % (v/v) imidazolium-class ionic liquid and covering the plates with a stationary phase based on RP-18 with F254S (10 × 20 cm). The presented results confirm that imidazolium tetrafluoroborate ionic liquids are efficient suppressors of free silanols, which are considered to be responsible for troublesome and irreproducible chromatographic determinations of basic compounds. 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| ispartof | Journal of chromatographic science, 2013-07, Vol.51 (6), p.560-565 |
| issn | 0021-9665 1945-239X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Acetonitriles - chemistry Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer - methods Densitometry - methods Imidazoles - chemistry Ionic Liquids - chemistry Naphazoline - analysis Naphazoline - chemistry Pharmaceutical Solutions - chemistry Spectrophotometry, Ultraviolet - methods |
| title | Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC-UV-Densitometric Method |
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