N-glycan analysis of human α1-antitrypsin produced in Chinese hamster ovary cells

Human alpha-1-antitrypsin (α1AT) is a glycoprotein with protease inhibitor activity protecting tissues from degradation. Patients with inherited α1AT deficiency are treated with native α1AT (nAT) purified from human plasma. In the present study, recombinant α1AT (rAT) was produced in Chinese hamster...

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Veröffentlicht in:	Glycoconjugate journal 2013-07, Vol.30 (5), p.537-547
Hauptverfasser:	Lee, Kyung Jin, Lee, Sang Mee, Gil, Jin Young, Kwon, Ohsuk, Kim, Jin Young, Park, Soon Jae, Chung, Hye-Shin, Oh, Doo-Byoung
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - chemistry alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin - isolation & purification Animals Biochemistry Biomedical and Life Sciences Carbohydrate Sequence CHO Cells Chromatography, High Pressure Liquid Cricetulus Enzyme Assays Glycosylation Half-Life Humans Kinetics Leukocyte Elastase - antagonists & inhibitors Life Sciences Molecular Sequence Data Pathology Polysaccharides - chemistry Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Sequence Homology, Amino Acid Swine
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