Learning from Nature: Advances in Geldanamycin- and Radicicol-Based Inhibitors of Hsp90

Natural products have been fundamental in the development of new therapeutic agents predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the influential role of the benzoquinone ansamycin geldanamycin and the resorcylic acid macrolactone radicicol not only in dri...

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Veröffentlicht in:	Journal of organic chemistry 2013-06, Vol.78 (11), p.5117-5141
Hauptverfasser:	Kitson, Russell R. A, Moody, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones - chemistry Benzoquinones - pharmacology HSP90 Heat-Shock Proteins - antagonists & inhibitors Lactams, Macrocyclic - chemistry Lactams, Macrocyclic - pharmacology Macrolides - chemistry Macrolides - pharmacology Models, Molecular Molecular Structure Structure-Activity Relationship
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