A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats
Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet–induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 2...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 2013-06, Vol.61 (6), p.505-512 |
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| creator | Chaturvedi, Upma Shrivastava, Atul Bhadauria, Smriti Saxena, Jitendra K Bhatia, Gitika |
| description | Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet–induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin–cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%–45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties. |
| doi_str_mv | 10.1097/FJC.0b013e31828b7822 |
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Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin–cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%–45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/FJC.0b013e31828b7822</identifier><identifier>PMID: 23429594</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Antioxidants - pharmacology ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; Cholesterol - blood ; Disease Models, Animal ; Disorders of blood lipids. Hyperlipoproteinemia ; Dyslipidemias - prevention & control ; General and cellular metabolism. Vitamins ; General pharmacology ; Hyperlipidemias - prevention & control ; In Vitro Techniques ; Lipoprotein Lipase - metabolism ; Male ; Medical sciences ; Metabolic diseases ; Oxidative Stress - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phosphatidylcholine-Sterol O-Acyltransferase - metabolism ; Plant Extracts - pharmacology ; Rats ; Seeds - chemistry ; Treatment Outcome ; Triglycerides - blood ; Trigonella - chemistry</subject><ispartof>Journal of cardiovascular pharmacology, 2013-06, Vol.61 (6), p.505-512</ispartof><rights>2013 Lippincott Williams & Wilkins, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3862-592ab005924af4eff7d9c076000e44f3230bd7f7ffe840976c32ccb30d75066d3</citedby><cites>FETCH-LOGICAL-c3862-592ab005924af4eff7d9c076000e44f3230bd7f7ffe840976c32ccb30d75066d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27567229$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23429594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaturvedi, Upma</creatorcontrib><creatorcontrib>Shrivastava, Atul</creatorcontrib><creatorcontrib>Bhadauria, Smriti</creatorcontrib><creatorcontrib>Saxena, Jitendra K</creatorcontrib><creatorcontrib>Bhatia, Gitika</creatorcontrib><title>A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet–induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin–cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%–45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Disease Models, Animal</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>Dyslipidemias - prevention & control</subject><subject>General and cellular metabolism. Vitamins</subject><subject>General pharmacology</subject><subject>Hyperlipidemias - prevention & control</subject><subject>In Vitro Techniques</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylcholine-Sterol O-Acyltransferase - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Seeds - chemistry</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Trigonella - chemistry</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEokPhDRDyBqksUm5sx06W1TBDQUVFbVlHjnM9Y-rEg520zGPxhniYaZFYsDr--c71vT5Z9rqA0wJq-X75eX4KLRQMWVHRqpUVpU-yWVEylnOg7Gk2g0JATjkXR9mLGL8DFLyU4nl2RBmndVnzWfbrjHxBvVaDjX3eqogd-bpWoVfaO7-yWjmyuFNuUqP1A_GGLIxJp3q7W98Eu_IDOqeI8ThMPVkFhTrpyTJtVwHx9h25RuwisQO5wtXkHgt92EZnN7bD3iqiho5c_rRdur1Dcj0GjH8s59sNhgdMkys1xpfZM6NcxFcHPc6-LRc38_P84vLjp_nZRa5ZJWhe1lS1AEm4MhyNkV2tQQoAQM4NowzaThppDFY8_afQjGrdMuhkCUJ07Dg72dfdBP9jwjg2vY16N-yAfopNwURZ18A4JJTvUR18jAFNswm2V2HbFNDswmpSWM2_YSXbm8MLU9tj92h6SCcBbw-AiikJE9SgbfzLyVJISuvEVXvu3rsRQ7x10z2GZo3Kjev_9_AbXhqx2w</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Chaturvedi, Upma</creator><creator>Shrivastava, Atul</creator><creator>Bhadauria, Smriti</creator><creator>Saxena, Jitendra K</creator><creator>Bhatia, Gitika</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats</title><author>Chaturvedi, Upma ; Shrivastava, Atul ; Bhadauria, Smriti ; Saxena, Jitendra K ; Bhatia, Gitika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3862-592ab005924af4eff7d9c076000e44f3230bd7f7ffe840976c32ccb30d75066d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Disease Models, Animal</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>Dyslipidemias - prevention & control</topic><topic>General and cellular metabolism. Vitamins</topic><topic>General pharmacology</topic><topic>Hyperlipidemias - prevention & control</topic><topic>In Vitro Techniques</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylcholine-Sterol O-Acyltransferase - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Seeds - chemistry</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Trigonella - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaturvedi, Upma</creatorcontrib><creatorcontrib>Shrivastava, Atul</creatorcontrib><creatorcontrib>Bhadauria, Smriti</creatorcontrib><creatorcontrib>Saxena, Jitendra K</creatorcontrib><creatorcontrib>Bhatia, Gitika</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaturvedi, Upma</au><au>Shrivastava, Atul</au><au>Bhadauria, Smriti</au><au>Saxena, Jitendra K</au><au>Bhatia, Gitika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>2013-06</date><risdate>2013</risdate><volume>61</volume><issue>6</issue><spage>505</spage><epage>512</epage><pages>505-512</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>Alcoholic extract of Trigonella foenum graecum seeds [fenugreek seed extract (FSE)] was studied in triton-induced and high-fat diet–induced hyperlipidemia to evaluate antidyslipidemic effect. Plasma cholesterol (26.19%) and triglycerides (36.6%) were found to be lowered by FSE maximum at a dose of 200 mg/kg body weight in triton-treated hyperlipidemic rats. Chronic feeding of FSE (200 mg/kg body weight) caused lowering in plasma and hepatic lipid levels by activating lecithin–cholesterol acyltransferase (47%), postheparin lipolytic activity (35%), triglyceride lipase (34%), lipoprotein lipase (20.8%), and increased excretion of fecal bile acids (36%–45%). The FSE shows potent antioxidant activity in both in vitro and in vivo systems. It inhibited generation of superoxide anion and hydroxyl free radicals in both enzymatic and nonenzymatic systems significantly at 200 µM concentration. Furthermore, FSE normalizes the activities of antioxidant enzymes, that is, superoxide dismutase and catalase, and reduces plasma lipid peroxidation (33.9%), hepatic 4-hydroxynonenal (27%), and isoprostanes (28%). Data of the present study demonstrated that the T. foenum graecum seed extract has both antidyslipidemic and antioxidant properties.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>23429594</pmid><doi>10.1097/FJC.0b013e31828b7822</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of cardiovascular pharmacology, 2013-06, Vol.61 (6), p.505-512 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Antioxidants - pharmacology Bile Acids and Salts - metabolism Biological and medical sciences Cholesterol - blood Disease Models, Animal Disorders of blood lipids. Hyperlipoproteinemia Dyslipidemias - prevention & control General and cellular metabolism. Vitamins General pharmacology Hyperlipidemias - prevention & control In Vitro Techniques Lipoprotein Lipase - metabolism Male Medical sciences Metabolic diseases Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphatidylcholine-Sterol O-Acyltransferase - metabolism Plant Extracts - pharmacology Rats Seeds - chemistry Treatment Outcome Triglycerides - blood Trigonella - chemistry |
| title | A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and Oxidative Stress in Hyperlipidemic Rats |
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