Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144

RATIONALE:Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Liver X nuclear receptors (LXRs) regulate the expression of the adenosine triphosphate–binding...

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Veröffentlicht in:	Circulation research 2013-06, Vol.112 (12), p.1592-1601
Hauptverfasser:	Ramírez, Cristina M, Rotllan, Noemi, Vlassov, Alexander V, Dávalos, Alberto, Li, Mu, Goedeke, Leigh, Aranda, Juan F, Cirera-Salinas, Daniel, Araldi, Elisa, Salerno, Alessandro, Wanschel, Amarylis, Zavadil, Jiri, Castrillo, Antonio, Kim, Jungsu, Suárez, Yajaira, Fernández-Hernando, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Apolipoprotein A-I - metabolism ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Chlorocebus aethiops Cholesterol, HDL - blood COS Cells Diet, High-Fat Gene Expression Profiling - methods Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Homeostasis Humans Hydrocarbons, Fluorinated - pharmacology Liver X Receptors Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism Oligonucleotide Array Sequence Analysis Oligonucleotides - metabolism Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism Sulfonamides - pharmacology
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