Locoregional Recurrence After Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Adverse Impact of Multifocal Disease and Potential Implications of Dose Escalation

Background Locoregional recurrence (LRR) rates following preoperative radiation therapy (RT) and radical resection for retroperitoneal sarcoma (RPS) are high. Targeted radiation dose escalation has been proposed as a means to decrease LRR, but is applicable only if LRRs are confined to within the RT...

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Veröffentlicht in:	Annals of surgical oncology 2013-07, Vol.20 (7), p.2140-2147
Hauptverfasser:	McBride, Sean M., Raut, Chandrajit P., Lapidus, Michelle, Devlin, Phillip M., Marcus, Karen J., Bertagnolli, Monica, George, Suzanne, Baldini, Elizabeth H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Brachytherapy Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - radiotherapy Neoplasms, Multiple Primary - complications Neoplasms, Multiple Primary - radiotherapy Neoplasms, Multiple Primary - surgery Oncology Radiation Oncology Radiotherapy Dosage Radiotherapy, Adjuvant Radiotherapy, Image-Guided Radiotherapy, Intensity-Modulated Retroperitoneal Neoplasms - pathology Retroperitoneal Neoplasms - radiotherapy Retroperitoneal Neoplasms - surgery Sarcoma - radiotherapy Sarcoma - secondary Sarcoma - surgery Smoking - adverse effects Surgery Surgical Oncology Survival Rate Tumor Burden Young Adult
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