Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats

Objectives To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats. Methods A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and val...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2013-07, Vol.65 (7), p.1064-1072
Hauptverfasser:	Peng, Can, Lv, Mengying, Tian, Jixin, Huang, Yin, Tian, Yuan, Zhang, Zunjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve artificial calculus bovis Biological Products Calculus Chlorpheniramine - pharmacokinetics chlorpheniramine maleate Chromatography Chromatography, High Pressure Liquid - methods Diclofenac - pharmacokinetics diclofenac sodium Drugs, Chinese Herbal - pharmacology Herb-Drug Interactions herb-drug pharmacokinetic interaction HPLC-MS/MS Limit of Detection Male Rats Rats, Wistar Sodium Studies Tandem Mass Spectrometry - methods Tissue Distribution
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