Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats
Objectives To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats. Methods A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and val...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2013-07, Vol.65 (7), p.1064-1072 |
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| container_title | Journal of pharmacy and pharmacology |
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| creator | Peng, Can Lv, Mengying Tian, Jixin Huang, Yin Tian, Yuan Zhang, Zunjian |
| description | Objectives
To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats.
Methods
A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous determination of DS and CPM in rat plasma. The proposed method was successfully applied to compare the herb–drug pharmacokinetic interaction of ACB with DS and CPM in rats following intragastric administration.
Key findings
The proposed method had good linearity and no endogenous material interfered with the analytes and internal standard peaks. The lower limit of quantification of DS and CPM was 1 and 0.1 ng/ml, respectively. There was no apparent pharmacokinetic interaction between DS and CPM. Co‐administration of ACB with DS noticeably increased the area under the concentration–time curve (AUC0‐∞) and peak plasma concentration (Cmax) of DS, while the parameters time of peak concentration (Tmax), clearance (ClZ/F) and apparent volume of distribution (VZ/F) of DS significantly decreased. Meanwhile, co‐administration of ACB with CPM noticeably increased the Tmax, ClZ/F and VZ/F of CPM. A marked decline in AUC0‐∞ and Cmax of CPM occurred in the presence of ACB.
Conclusions
This study indicated that co‐administration of ACB with DS and CPM can result in an apparent herb–drug pharmacokinetic interaction in rats. |
| doi_str_mv | 10.1111/jphp.12069 |
| format | Article |
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To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats.
Methods
A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous determination of DS and CPM in rat plasma. The proposed method was successfully applied to compare the herb–drug pharmacokinetic interaction of ACB with DS and CPM in rats following intragastric administration.
Key findings
The proposed method had good linearity and no endogenous material interfered with the analytes and internal standard peaks. The lower limit of quantification of DS and CPM was 1 and 0.1 ng/ml, respectively. There was no apparent pharmacokinetic interaction between DS and CPM. Co‐administration of ACB with DS noticeably increased the area under the concentration–time curve (AUC0‐∞) and peak plasma concentration (Cmax) of DS, while the parameters time of peak concentration (Tmax), clearance (ClZ/F) and apparent volume of distribution (VZ/F) of DS significantly decreased. Meanwhile, co‐administration of ACB with CPM noticeably increased the Tmax, ClZ/F and VZ/F of CPM. A marked decline in AUC0‐∞ and Cmax of CPM occurred in the presence of ACB.
Conclusions
This study indicated that co‐administration of ACB with DS and CPM can result in an apparent herb–drug pharmacokinetic interaction in rats.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.12069</identifier><identifier>PMID: 23738734</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Area Under Curve ; artificial calculus bovis ; Biological Products ; Calculus ; Chlorpheniramine - pharmacokinetics ; chlorpheniramine maleate ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Diclofenac - pharmacokinetics ; diclofenac sodium ; Drugs, Chinese Herbal - pharmacology ; Herb-Drug Interactions ; herb-drug pharmacokinetic interaction ; HPLC-MS/MS ; Limit of Detection ; Male ; Rats ; Rats, Wistar ; Sodium ; Studies ; Tandem Mass Spectrometry - methods ; Tissue Distribution</subject><ispartof>Journal of pharmacy and pharmacology, 2013-07, Vol.65 (7), p.1064-1072</ispartof><rights>2013 Royal Pharmaceutical Society</rights><rights>2013 Royal Pharmaceutical Society.</rights><rights>Copyright © 2013 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4319-e9aa13499701e5eb40a11efc1ca5004ff4c16ee833df5dfbd3170608f7cda4513</citedby><cites>FETCH-LOGICAL-c4319-e9aa13499701e5eb40a11efc1ca5004ff4c16ee833df5dfbd3170608f7cda4513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.12069$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.12069$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23738734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Can</creatorcontrib><creatorcontrib>Lv, Mengying</creatorcontrib><creatorcontrib>Tian, Jixin</creatorcontrib><creatorcontrib>Huang, Yin</creatorcontrib><creatorcontrib>Tian, Yuan</creatorcontrib><creatorcontrib>Zhang, Zunjian</creatorcontrib><title>Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives
To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats.
Methods
A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous determination of DS and CPM in rat plasma. The proposed method was successfully applied to compare the herb–drug pharmacokinetic interaction of ACB with DS and CPM in rats following intragastric administration.
Key findings
The proposed method had good linearity and no endogenous material interfered with the analytes and internal standard peaks. The lower limit of quantification of DS and CPM was 1 and 0.1 ng/ml, respectively. There was no apparent pharmacokinetic interaction between DS and CPM. Co‐administration of ACB with DS noticeably increased the area under the concentration–time curve (AUC0‐∞) and peak plasma concentration (Cmax) of DS, while the parameters time of peak concentration (Tmax), clearance (ClZ/F) and apparent volume of distribution (VZ/F) of DS significantly decreased. Meanwhile, co‐administration of ACB with CPM noticeably increased the Tmax, ClZ/F and VZ/F of CPM. A marked decline in AUC0‐∞ and Cmax of CPM occurred in the presence of ACB.
Conclusions
This study indicated that co‐administration of ACB with DS and CPM can result in an apparent herb–drug pharmacokinetic interaction in rats.</description><subject>Animals</subject><subject>Area Under Curve</subject><subject>artificial calculus bovis</subject><subject>Biological Products</subject><subject>Calculus</subject><subject>Chlorpheniramine - pharmacokinetics</subject><subject>chlorpheniramine maleate</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Diclofenac - pharmacokinetics</subject><subject>diclofenac sodium</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Herb-Drug Interactions</subject><subject>herb-drug pharmacokinetic interaction</subject><subject>HPLC-MS/MS</subject><subject>Limit of Detection</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium</subject><subject>Studies</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Tissue Distribution</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEotvChR-ALHFBSCl2_LU5QoEuqIIeQCAu1sQZE2-dONhJSy_8drJs2wMHRiPN5XkfjfQWxRNGj9kyL7djNx6ziqr6XrGqqKhKzeT6frGitKpKLjU_KA5z3lJKtVLqYXFQcc3XmotV8XuDqSnbNP8gYwepBxsv_ICTt8QPEyawk48DiY5Amrzz1kMgFoKdw5xJEy99Jld-6kjrbYgOB7Akx9bPPYGhJbYLMY0dDj5Bv3hJDwFhwkVOEkz5UfHAQcj4-OYeFV_evf18sinPPp2-P3l1VlrBWV1iDcC4qGtNGUpsBAXG0FlmQVIqnBOWKcQ1562TrWtazjRVdO20bUFIxo-K53vvmOLPGfNkep8thgADxjkbxpWs18uKBX32D7qNcxqW73aUqKkSlVqoF3vKpphzQmfG5HtI14ZRs2vF7Foxf1tZ4Kc3yrnpsb1Db2tYALYHrnzA6_-ozIfzzfmttNxnfJ7w110G0oVRmmtpvn48Nfzbd1nJ17V5w_8AsL-o1A</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Peng, Can</creator><creator>Lv, Mengying</creator><creator>Tian, Jixin</creator><creator>Huang, Yin</creator><creator>Tian, Yuan</creator><creator>Zhang, Zunjian</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats</title><author>Peng, Can ; Lv, Mengying ; Tian, Jixin ; Huang, Yin ; Tian, Yuan ; Zhang, Zunjian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4319-e9aa13499701e5eb40a11efc1ca5004ff4c16ee833df5dfbd3170608f7cda4513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Area Under Curve</topic><topic>artificial calculus bovis</topic><topic>Biological Products</topic><topic>Calculus</topic><topic>Chlorpheniramine - pharmacokinetics</topic><topic>chlorpheniramine maleate</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Diclofenac - pharmacokinetics</topic><topic>diclofenac sodium</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Herb-Drug Interactions</topic><topic>herb-drug pharmacokinetic interaction</topic><topic>HPLC-MS/MS</topic><topic>Limit of Detection</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium</topic><topic>Studies</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Can</creatorcontrib><creatorcontrib>Lv, Mengying</creatorcontrib><creatorcontrib>Tian, Jixin</creatorcontrib><creatorcontrib>Huang, Yin</creatorcontrib><creatorcontrib>Tian, Yuan</creatorcontrib><creatorcontrib>Zhang, Zunjian</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Can</au><au>Lv, Mengying</au><au>Tian, Jixin</au><au>Huang, Yin</au><au>Tian, Yuan</au><au>Zhang, Zunjian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2013-07</date><risdate>2013</risdate><volume>65</volume><issue>7</issue><spage>1064</spage><epage>1072</epage><pages>1064-1072</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>Objectives
To investigate the herb–drug pharmacokinetic interaction of artificial calculus bovis (ACB) with diclofenac sodium (DS) and chlorpheniramine maleate (CPM) in rats.
Methods
A sensitive high‐performance liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous determination of DS and CPM in rat plasma. The proposed method was successfully applied to compare the herb–drug pharmacokinetic interaction of ACB with DS and CPM in rats following intragastric administration.
Key findings
The proposed method had good linearity and no endogenous material interfered with the analytes and internal standard peaks. The lower limit of quantification of DS and CPM was 1 and 0.1 ng/ml, respectively. There was no apparent pharmacokinetic interaction between DS and CPM. Co‐administration of ACB with DS noticeably increased the area under the concentration–time curve (AUC0‐∞) and peak plasma concentration (Cmax) of DS, while the parameters time of peak concentration (Tmax), clearance (ClZ/F) and apparent volume of distribution (VZ/F) of DS significantly decreased. Meanwhile, co‐administration of ACB with CPM noticeably increased the Tmax, ClZ/F and VZ/F of CPM. A marked decline in AUC0‐∞ and Cmax of CPM occurred in the presence of ACB.
Conclusions
This study indicated that co‐administration of ACB with DS and CPM can result in an apparent herb–drug pharmacokinetic interaction in rats.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23738734</pmid><doi>10.1111/jphp.12069</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE; Oxford Journals - Connect here FIRST to enable access |
| subjects | Animals Area Under Curve artificial calculus bovis Biological Products Calculus Chlorpheniramine - pharmacokinetics chlorpheniramine maleate Chromatography Chromatography, High Pressure Liquid - methods Diclofenac - pharmacokinetics diclofenac sodium Drugs, Chinese Herbal - pharmacology Herb-Drug Interactions herb-drug pharmacokinetic interaction HPLC-MS/MS Limit of Detection Male Rats Rats, Wistar Sodium Studies Tandem Mass Spectrometry - methods Tissue Distribution |
| title | Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats |
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