Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors
Metabolic syndrome (MS) may influence vascular reactivity and might cause an excessive increase in blood pressure (BP) during dynamic exercise. We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response o...
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| Veröffentlicht in: | Hypertension research 2013-06, Vol.36 (6), p.534-539 |
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| container_title | Hypertension research |
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| creator | Miyai, Nobuyuki Shiozaki, Maki Yabu, Mayuko Utsumi, Miyoko Morioka, Ikuharu Miyashita, Kazuhisa Arita, Mikio |
| description | Metabolic syndrome (MS) may influence vascular reactivity and might cause an excessive increase in blood pressure (BP) during dynamic exercise. We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response of BP to exercise was assessed by the mean arterial pressure (MAP) during bicycle ergometry. The MAP values were expressed as z-scores normalized to the relative increases in heart rate. High-normal BP, dyslipidemia and hyperglycemia were diagnosed according to the Japan-specific MS criteria. The z-score of MAP was significantly higher in subjects with high-normal BP (+0.57, P |
| doi_str_mv | 10.1038/hr.2012.215 |
| format | Article |
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We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response of BP to exercise was assessed by the mean arterial pressure (MAP) during bicycle ergometry. The MAP values were expressed as z-scores normalized to the relative increases in heart rate. High-normal BP, dyslipidemia and hyperglycemia were diagnosed according to the Japan-specific MS criteria. The z-score of MAP was significantly higher in subjects with high-normal BP (+0.57, P<0.001), dyslipidemia (+0.18, P<0.001) and hyperglycemia (+0.24, P<0.001) than in those without MS component (-0.38). In the high-normal BP subjects, the addition of dyslipidemia and/or hyperglycemia was associated with a progressive increase in the z-score of exercise MAP, whereas no such association was observed in the normal-BP subjects (P=0.033, two-way ANOVA). Multivariate regression analysis revealed that a greater number of MS components (β=0.102, P=0.010) was an independent determinant of increased MAP z-score after adjustment for potential confounders, including age (β=0.123, P<0.001), body mass index (β=0.145, P<0.001) and high-normal BP (β=0.410, P<0.001). These results suggest that accumulation of MS components may alter vascular structure and function and lead to the significant elevation of MAP during dynamic exercise even before clinical manifestation of arterial hypertension.]]></description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2012.215</identifier><identifier>PMID: 23344132</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Analysis of Variance ; Anthropometry ; Arterial Pressure - physiology ; Blood Glucose - metabolism ; Body Mass Index ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Data Interpretation, Statistical ; Exercise - physiology ; Exercise Test ; Heart Rate - physiology ; Humans ; Male ; Metabolic Diseases - physiopathology ; Middle Aged ; Oxygen Consumption - physiology ; Risk Factors ; Smoking - physiopathology ; Triglycerides - blood ; Young Adult</subject><ispartof>Hypertension research, 2013-06, Vol.36 (6), p.534-539</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-f072ae949ffd531e52a2cde594a909f6c0a07208c14083f54ff8e9b0e0af9f0f3</citedby><cites>FETCH-LOGICAL-c355t-f072ae949ffd531e52a2cde594a909f6c0a07208c14083f54ff8e9b0e0af9f0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23344132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyai, Nobuyuki</creatorcontrib><creatorcontrib>Shiozaki, Maki</creatorcontrib><creatorcontrib>Yabu, Mayuko</creatorcontrib><creatorcontrib>Utsumi, Miyoko</creatorcontrib><creatorcontrib>Morioka, Ikuharu</creatorcontrib><creatorcontrib>Miyashita, Kazuhisa</creatorcontrib><creatorcontrib>Arita, Mikio</creatorcontrib><title>Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description><![CDATA[Metabolic syndrome (MS) may influence vascular reactivity and might cause an excessive increase in blood pressure (BP) during dynamic exercise. We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response of BP to exercise was assessed by the mean arterial pressure (MAP) during bicycle ergometry. The MAP values were expressed as z-scores normalized to the relative increases in heart rate. High-normal BP, dyslipidemia and hyperglycemia were diagnosed according to the Japan-specific MS criteria. The z-score of MAP was significantly higher in subjects with high-normal BP (+0.57, P<0.001), dyslipidemia (+0.18, P<0.001) and hyperglycemia (+0.24, P<0.001) than in those without MS component (-0.38). In the high-normal BP subjects, the addition of dyslipidemia and/or hyperglycemia was associated with a progressive increase in the z-score of exercise MAP, whereas no such association was observed in the normal-BP subjects (P=0.033, two-way ANOVA). Multivariate regression analysis revealed that a greater number of MS components (β=0.102, P=0.010) was an independent determinant of increased MAP z-score after adjustment for potential confounders, including age (β=0.123, P<0.001), body mass index (β=0.145, P<0.001) and high-normal BP (β=0.410, P<0.001). These results suggest that accumulation of MS components may alter vascular structure and function and lead to the significant elevation of MAP during dynamic exercise even before clinical manifestation of arterial hypertension.]]></description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anthropometry</subject><subject>Arterial Pressure - physiology</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Data Interpretation, Statistical</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Diseases - physiopathology</subject><subject>Middle Aged</subject><subject>Oxygen Consumption - physiology</subject><subject>Risk Factors</subject><subject>Smoking - physiopathology</subject><subject>Triglycerides - blood</subject><subject>Young Adult</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAURoMozvhYuZcsBemYZ22WMvgYENzoumTSGybaNjU39YF_3g4-Vh9czj2LQ8gJZwvOZHWxSQvBuFgIrnfInEtVFUpwtUvmzPCyMKUsZ-QA8ZkxUWnD98lMSKkUl2JOvla9S2ARGtqB7alNGVKwLR0SII4J6LRD7BFojrT57G0XHIUPSC5Mt9DTPqYuZugxvAHFcf0MLiN9D3lDu7HNYWhhUme7ju30mQK-UG9djgmPyJ63LcLx7x6Sp5vrx-Vdcf9wu1pe3RdOap0Lzy6FBaOM942WHLSwwjWgjbKGGV86ZieCVY4rVkmvlfcVmDUDZr3xzMtDcvbjHVJ8HQFz3QV00La2hzhizWWpNTOykhN6_oO6FBET-HpIobPps-as3tauN6ne1q6n2hN9-ise1x00_-xfXvkNv4V90Q</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Miyai, Nobuyuki</creator><creator>Shiozaki, Maki</creator><creator>Yabu, Mayuko</creator><creator>Utsumi, Miyoko</creator><creator>Morioka, Ikuharu</creator><creator>Miyashita, Kazuhisa</creator><creator>Arita, Mikio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors</title><author>Miyai, Nobuyuki ; Shiozaki, Maki ; Yabu, Mayuko ; Utsumi, Miyoko ; Morioka, Ikuharu ; Miyashita, Kazuhisa ; Arita, Mikio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-f072ae949ffd531e52a2cde594a909f6c0a07208c14083f54ff8e9b0e0af9f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anthropometry</topic><topic>Arterial Pressure - physiology</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Data Interpretation, Statistical</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Diseases - physiopathology</topic><topic>Middle Aged</topic><topic>Oxygen Consumption - physiology</topic><topic>Risk Factors</topic><topic>Smoking - physiopathology</topic><topic>Triglycerides - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyai, Nobuyuki</creatorcontrib><creatorcontrib>Shiozaki, Maki</creatorcontrib><creatorcontrib>Yabu, Mayuko</creatorcontrib><creatorcontrib>Utsumi, Miyoko</creatorcontrib><creatorcontrib>Morioka, Ikuharu</creatorcontrib><creatorcontrib>Miyashita, Kazuhisa</creatorcontrib><creatorcontrib>Arita, Mikio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyai, Nobuyuki</au><au>Shiozaki, Maki</au><au>Yabu, Mayuko</au><au>Utsumi, Miyoko</au><au>Morioka, Ikuharu</au><au>Miyashita, Kazuhisa</au><au>Arita, Mikio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>36</volume><issue>6</issue><spage>534</spage><epage>539</epage><pages>534-539</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract><![CDATA[Metabolic syndrome (MS) may influence vascular reactivity and might cause an excessive increase in blood pressure (BP) during dynamic exercise. We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response of BP to exercise was assessed by the mean arterial pressure (MAP) during bicycle ergometry. The MAP values were expressed as z-scores normalized to the relative increases in heart rate. High-normal BP, dyslipidemia and hyperglycemia were diagnosed according to the Japan-specific MS criteria. The z-score of MAP was significantly higher in subjects with high-normal BP (+0.57, P<0.001), dyslipidemia (+0.18, P<0.001) and hyperglycemia (+0.24, P<0.001) than in those without MS component (-0.38). In the high-normal BP subjects, the addition of dyslipidemia and/or hyperglycemia was associated with a progressive increase in the z-score of exercise MAP, whereas no such association was observed in the normal-BP subjects (P=0.033, two-way ANOVA). Multivariate regression analysis revealed that a greater number of MS components (β=0.102, P=0.010) was an independent determinant of increased MAP z-score after adjustment for potential confounders, including age (β=0.123, P<0.001), body mass index (β=0.145, P<0.001) and high-normal BP (β=0.410, P<0.001). These results suggest that accumulation of MS components may alter vascular structure and function and lead to the significant elevation of MAP during dynamic exercise even before clinical manifestation of arterial hypertension.]]></abstract><cop>England</cop><pmid>23344132</pmid><doi>10.1038/hr.2012.215</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis of Variance Anthropometry Arterial Pressure - physiology Blood Glucose - metabolism Body Mass Index Cholesterol - blood Cholesterol, HDL - blood Cross-Sectional Studies Data Interpretation, Statistical Exercise - physiology Exercise Test Heart Rate - physiology Humans Male Metabolic Diseases - physiopathology Middle Aged Oxygen Consumption - physiology Risk Factors Smoking - physiopathology Triglycerides - blood Young Adult |
| title | Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors |
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