Overexpression of mitofusin 2 improves translocation of glucose transporter 4 in skeletal muscle of high-fat diet-fed rats through AMP-activated protein kinase signaling

Mitofusin 2 (Mfn2) is a mitochondrial membrane protein that plays a role in mitochondrial fusion and metabolism in mammalian cells. Previous studies have reported a positive correlation between Mfn2 expression and insulin sensitivity in non-diabetic and type 2 diabetic subjects. Thus, the aim of the...

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Veröffentlicht in:	Molecular medicine reports 2013-07, Vol.8 (1), p.205-210
Hauptverfasser:	KONG, DEXIAN, SONG, GUANGYAO, WANG, CHAO, MA, HUIJUAN, REN, LUPING, NIE, QIAN, ZHANG, XUEMEI, GAN, KEXIN
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP AMP-activated protein kinase AMP-Activated Protein Kinases Animals Blood Glucose Diabetes mellitus Diet, High-Fat Expression vectors Fatty Acids - blood Gene Expression Gene Expression Regulation Glucose Glucose - metabolism Glucose tolerance Glucose transporter glucose transporter 4 Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism High fat diet Homeostasis Insulin Insulin - metabolism Insulin resistance Intolerance Kinases Male Mammalian cells Membrane proteins Membrane Proteins - genetics Mitochondria Mitochondrial DNA Mitochondrial Proteins - genetics mitofusin 2 mRNA Muscle, Skeletal - metabolism Polymerase chain reaction Protein Transport Proto-Oncogene Proteins c-akt - metabolism Rats Rodents Signal Transduction Skeletal muscle
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