Nerve Injury-Induced Protein 1 (Ninjurin-1) Is a Novel Therapeutic Target for Cavernous Nerve Injury-Induced Erectile Dysfunction in Mice

Radical prostatectomy for prostate cancer can not only induce cavernous nerve injury (CNI) but also result in structural changes in the cavernous tissues. Nerve injuryinduced protein 1, Ninjurin1 (Ninj1), is known to be involved in neuroinflammatory processes and to be related to vascular regression...

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Veröffentlicht in:	Journal of sexual medicine 2013-06, Vol.10 (6), p.1488-1501
Hauptverfasser:	Yin, Guo Nan, Kim, Woo Jean, Jin, HaiRong, Kwon, MiHye, Song, KangMoon, Choi, Min Ji, Park, JinMi, Das, Nando Dulal, Kwon, KiDong, Batbold, Dulguun, Kim, KyuWon, Ryu, JiKan, Suh, JunKyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 - metabolism Angiopoietin-2 - metabolism Animals Antibodies, Neutralizing - administration & dosage Antibodies, Neutralizing - pharmacology Cavernous Nerve Injury Cell Adhesion Molecules, Neuronal - antagonists & inhibitors Cell Adhesion Molecules, Neuronal - immunology Cell Proliferation - drug effects Disease Models, Animal Electric Stimulation Endothelial Cells - drug effects Endothelial Cells - enzymology Erectile Dysfunction Erectile Dysfunction - drug therapy Erectile Dysfunction - metabolism Fibrosis Injections Male Mice Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Nerve Crush Nerve Growth Factors - antagonists & inhibitors Nerve Growth Factors - immunology Nerve Regeneration - drug effects Ninj1 Protein Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type III - metabolism Penile Erection - drug effects Penis Penis - drug effects Penis - innervation Penis - pathology Phosphorylation Prostatectomy Proto-Oncogene Proteins c-akt - metabolism
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