The effects of hyaluronic acid and carboxymethylcellulose in preventing recurrence of urethral stricture after endoscopic internal urethrotomy: a multicenter, randomized controlled, single-blinded study
To evaluate the effects of hyaluronic acid (HA) and carboxymethylcellulose (CMC) on the recurrence of urethral stricture after treatment with endoscopic internal urethrotomy (EIU). A total of 120 patients underwent EIU for urethral stricture. Recruited patients were randomly divided into two groups:...
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| Veröffentlicht in: | Journal of endourology 2013-06, Vol.27 (6), p.756-762 |
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| container_title | Journal of endourology |
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| creator | Chung, Jae Hoon Kang, Dong Hyuk Choi, Hong Yong Jeong, Tae Yoong Ha, U-Syn Han, Jun Hyun Yu, Ji Hyeong Cho, Jeong Man Yoo, Tag Keun Park, Jinsung Kim, Tae Hyo Lee, Seung Wook |
| description | To evaluate the effects of hyaluronic acid (HA) and carboxymethylcellulose (CMC) on the recurrence of urethral stricture after treatment with endoscopic internal urethrotomy (EIU).
A total of 120 patients underwent EIU for urethral stricture. Recruited patients were randomly divided into two groups: group A and B. Patients in group A (60 patients, experimental group) received HA/CMC instillation and patients in group B (60 patients, control group) received lubricant instillation after internal urethrotomy. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of HA/CMC instillation was evaluated based on the International Prostate Symptom Score/Quality of Life, peak urine flow rate, voided volume and postvoiding residual urine volume. The visual analogue scale (VAS) pain score and degree of satisfaction were also determined for each participant.
Among 120 initial participants, 53 patients in group A and 48 patients in group B had completed the experiment. VAS pain scores were 0.67±0.76 and 3.60±1.52 (p |
| doi_str_mv | 10.1089/end.2012.0613 |
| format | Article |
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A total of 120 patients underwent EIU for urethral stricture. Recruited patients were randomly divided into two groups: group A and B. Patients in group A (60 patients, experimental group) received HA/CMC instillation and patients in group B (60 patients, control group) received lubricant instillation after internal urethrotomy. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of HA/CMC instillation was evaluated based on the International Prostate Symptom Score/Quality of Life, peak urine flow rate, voided volume and postvoiding residual urine volume. The visual analogue scale (VAS) pain score and degree of satisfaction were also determined for each participant.
Among 120 initial participants, 53 patients in group A and 48 patients in group B had completed the experiment. VAS pain scores were 0.67±0.76 and 3.60±1.52 (p<0.001), and degrees of satisfaction were 0.28±0.50 and 0.80±0.81 in group A and group B at 1 month after surgery (p=0.001). The recurrence of urethral stricture was observed in five cases (9.4%) in group A and 11 (22.9%) in group B (p=0.029).
HA/CMC instillation during EIU may decrease the incidence of urethral stricture recurrence. In addition, the use of HA/CMC was effective in reducing pain during the early postoperative period without an adverse effect.</description><identifier>ISSN: 0892-7790</identifier><identifier>EISSN: 1557-900X</identifier><identifier>DOI: 10.1089/end.2012.0613</identifier><identifier>PMID: 23470209</identifier><language>eng</language><publisher>United States</publisher><subject>Carboxymethylcellulose Sodium - therapeutic use ; Endoscopy ; Humans ; Hyaluronic Acid - therapeutic use ; Male ; Middle Aged ; Recurrence ; Single-Blind Method ; Urethra - surgery ; Urethral Stricture - prevention & control ; Urethral Stricture - surgery ; Urologic Surgical Procedures, Male - methods</subject><ispartof>Journal of endourology, 2013-06, Vol.27 (6), p.756-762</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-e5e1bc63261c0df6a6f3ce41396e83838c7473fa920413faf122e0043386fc1b3</citedby><cites>FETCH-LOGICAL-c293t-e5e1bc63261c0df6a6f3ce41396e83838c7473fa920413faf122e0043386fc1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23470209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Jae Hoon</creatorcontrib><creatorcontrib>Kang, Dong Hyuk</creatorcontrib><creatorcontrib>Choi, Hong Yong</creatorcontrib><creatorcontrib>Jeong, Tae Yoong</creatorcontrib><creatorcontrib>Ha, U-Syn</creatorcontrib><creatorcontrib>Han, Jun Hyun</creatorcontrib><creatorcontrib>Yu, Ji Hyeong</creatorcontrib><creatorcontrib>Cho, Jeong Man</creatorcontrib><creatorcontrib>Yoo, Tag Keun</creatorcontrib><creatorcontrib>Park, Jinsung</creatorcontrib><creatorcontrib>Kim, Tae Hyo</creatorcontrib><creatorcontrib>Lee, Seung Wook</creatorcontrib><title>The effects of hyaluronic acid and carboxymethylcellulose in preventing recurrence of urethral stricture after endoscopic internal urethrotomy: a multicenter, randomized controlled, single-blinded study</title><title>Journal of endourology</title><addtitle>J Endourol</addtitle><description>To evaluate the effects of hyaluronic acid (HA) and carboxymethylcellulose (CMC) on the recurrence of urethral stricture after treatment with endoscopic internal urethrotomy (EIU).
A total of 120 patients underwent EIU for urethral stricture. Recruited patients were randomly divided into two groups: group A and B. Patients in group A (60 patients, experimental group) received HA/CMC instillation and patients in group B (60 patients, control group) received lubricant instillation after internal urethrotomy. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of HA/CMC instillation was evaluated based on the International Prostate Symptom Score/Quality of Life, peak urine flow rate, voided volume and postvoiding residual urine volume. The visual analogue scale (VAS) pain score and degree of satisfaction were also determined for each participant.
Among 120 initial participants, 53 patients in group A and 48 patients in group B had completed the experiment. VAS pain scores were 0.67±0.76 and 3.60±1.52 (p<0.001), and degrees of satisfaction were 0.28±0.50 and 0.80±0.81 in group A and group B at 1 month after surgery (p=0.001). The recurrence of urethral stricture was observed in five cases (9.4%) in group A and 11 (22.9%) in group B (p=0.029).
HA/CMC instillation during EIU may decrease the incidence of urethral stricture recurrence. In addition, the use of HA/CMC was effective in reducing pain during the early postoperative period without an adverse effect.</description><subject>Carboxymethylcellulose Sodium - therapeutic use</subject><subject>Endoscopy</subject><subject>Humans</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Recurrence</subject><subject>Single-Blind Method</subject><subject>Urethra - surgery</subject><subject>Urethral Stricture - prevention & control</subject><subject>Urethral Stricture - surgery</subject><subject>Urologic Surgical Procedures, Male - methods</subject><issn>0892-7790</issn><issn>1557-900X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9v1DAQxS0EotvCkSvykUOzjO382XBDFVCkSlyKxC1ynDFr5NiL7aCGj8inYqItyAfL8356fprH2CsBewGH_i2GaS9ByD20Qj1hO9E0XdUDfHvKdqTLqut6uGCXOf8AEIqg5-xCqroDCf2O_bk_Ikdr0ZTMo-XHVfslxeAM18ZNXIeJG53G-LDOWI6rN-j94mNG7gI_JfyFobjwnSc0S0oYDG42SyI4ac9zSc4UenJtCyZOcWM28UT-LtAgEHOGY4nz-o5rPi--OIObes0TBYiz-40UI4aSovc4XfNMX3qsRu_CRFIuy7S-YM-s9hlfPt5X7OvHD_c3t9Xdl0-fb97fVUb2qlTYoBhNq2QrDEy21a1VBmuh-hYPio7p6k5Z3UugodVWSIkAtVKH1hoxqiv25ux7SvHngrkMs8vbWnTAuOSBltxAU0MLhFZn1KSYc0I7nJKbdVoHAcNW30D7GLb6hq0-4l8_Wi_jjNN_-l9f6i9FT5y-</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Chung, Jae Hoon</creator><creator>Kang, Dong Hyuk</creator><creator>Choi, Hong Yong</creator><creator>Jeong, Tae Yoong</creator><creator>Ha, U-Syn</creator><creator>Han, Jun Hyun</creator><creator>Yu, Ji Hyeong</creator><creator>Cho, Jeong Man</creator><creator>Yoo, Tag Keun</creator><creator>Park, Jinsung</creator><creator>Kim, Tae Hyo</creator><creator>Lee, Seung Wook</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>The effects of hyaluronic acid and carboxymethylcellulose in preventing recurrence of urethral stricture after endoscopic internal urethrotomy: a multicenter, randomized controlled, single-blinded study</title><author>Chung, Jae Hoon ; Kang, Dong Hyuk ; Choi, Hong Yong ; Jeong, Tae Yoong ; Ha, U-Syn ; Han, Jun Hyun ; Yu, Ji Hyeong ; Cho, Jeong Man ; Yoo, Tag Keun ; Park, Jinsung ; Kim, Tae Hyo ; Lee, Seung Wook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-e5e1bc63261c0df6a6f3ce41396e83838c7473fa920413faf122e0043386fc1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Carboxymethylcellulose Sodium - therapeutic use</topic><topic>Endoscopy</topic><topic>Humans</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Recurrence</topic><topic>Single-Blind Method</topic><topic>Urethra - surgery</topic><topic>Urethral Stricture - prevention & control</topic><topic>Urethral Stricture - surgery</topic><topic>Urologic Surgical Procedures, Male - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Jae Hoon</creatorcontrib><creatorcontrib>Kang, Dong Hyuk</creatorcontrib><creatorcontrib>Choi, Hong Yong</creatorcontrib><creatorcontrib>Jeong, Tae Yoong</creatorcontrib><creatorcontrib>Ha, U-Syn</creatorcontrib><creatorcontrib>Han, Jun Hyun</creatorcontrib><creatorcontrib>Yu, Ji Hyeong</creatorcontrib><creatorcontrib>Cho, Jeong Man</creatorcontrib><creatorcontrib>Yoo, Tag Keun</creatorcontrib><creatorcontrib>Park, Jinsung</creatorcontrib><creatorcontrib>Kim, Tae Hyo</creatorcontrib><creatorcontrib>Lee, Seung Wook</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endourology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Jae Hoon</au><au>Kang, Dong Hyuk</au><au>Choi, Hong Yong</au><au>Jeong, Tae Yoong</au><au>Ha, U-Syn</au><au>Han, Jun Hyun</au><au>Yu, Ji Hyeong</au><au>Cho, Jeong Man</au><au>Yoo, Tag Keun</au><au>Park, Jinsung</au><au>Kim, Tae Hyo</au><au>Lee, Seung Wook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of hyaluronic acid and carboxymethylcellulose in preventing recurrence of urethral stricture after endoscopic internal urethrotomy: a multicenter, randomized controlled, single-blinded study</atitle><jtitle>Journal of endourology</jtitle><addtitle>J Endourol</addtitle><date>2013-06</date><risdate>2013</risdate><volume>27</volume><issue>6</issue><spage>756</spage><epage>762</epage><pages>756-762</pages><issn>0892-7790</issn><eissn>1557-900X</eissn><abstract>To evaluate the effects of hyaluronic acid (HA) and carboxymethylcellulose (CMC) on the recurrence of urethral stricture after treatment with endoscopic internal urethrotomy (EIU).
A total of 120 patients underwent EIU for urethral stricture. Recruited patients were randomly divided into two groups: group A and B. Patients in group A (60 patients, experimental group) received HA/CMC instillation and patients in group B (60 patients, control group) received lubricant instillation after internal urethrotomy. Each patient was evaluated at 4 weeks (V1), 12 weeks (V2), and 24 weeks (V3) after the surgery. The effectiveness of HA/CMC instillation was evaluated based on the International Prostate Symptom Score/Quality of Life, peak urine flow rate, voided volume and postvoiding residual urine volume. The visual analogue scale (VAS) pain score and degree of satisfaction were also determined for each participant.
Among 120 initial participants, 53 patients in group A and 48 patients in group B had completed the experiment. VAS pain scores were 0.67±0.76 and 3.60±1.52 (p<0.001), and degrees of satisfaction were 0.28±0.50 and 0.80±0.81 in group A and group B at 1 month after surgery (p=0.001). The recurrence of urethral stricture was observed in five cases (9.4%) in group A and 11 (22.9%) in group B (p=0.029).
HA/CMC instillation during EIU may decrease the incidence of urethral stricture recurrence. In addition, the use of HA/CMC was effective in reducing pain during the early postoperative period without an adverse effect.</abstract><cop>United States</cop><pmid>23470209</pmid><doi>10.1089/end.2012.0613</doi><tpages>7</tpages></addata></record> |
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| subjects | Carboxymethylcellulose Sodium - therapeutic use Endoscopy Humans Hyaluronic Acid - therapeutic use Male Middle Aged Recurrence Single-Blind Method Urethra - surgery Urethral Stricture - prevention & control Urethral Stricture - surgery Urologic Surgical Procedures, Male - methods |
| title | The effects of hyaluronic acid and carboxymethylcellulose in preventing recurrence of urethral stricture after endoscopic internal urethrotomy: a multicenter, randomized controlled, single-blinded study |
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