Carrier-free combination for dry powder inhalation of antibiotics in the treatment of lung infections in cystic fibrosis

The aim of the study was to develop an efficient combination antibiotic formulation containing tobramycin and clarithromycin as a dry powder for inhalation. A carrier-free formulation of the two drugs was produced by spray-drying and characterised for its aerodynamic behaviour by impaction tests wit...

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Veröffentlicht in:	International journal of pharmaceutics 2013-07, Vol.451 (1-2), p.112-120
Hauptverfasser:	Pilcer, Gabrielle, De Bueger, Véronique, Traina, Karl, Traore, Hamidou, Sebti, Thami, Vanderbist, Francis, Amighi, Karim
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Bacterial Infections - drug therapy Bacterial Infections - etiology Carrier-free Clarithromycin Clarithromycin - administration & dosage Clarithromycin - pharmacokinetics Crystallization Cystic Fibrosis - complications Cystic Fibrosis - drug therapy Drug Combinations Drug Compounding Drug Synergism Dry powder inhaler (DPI) Dry Powder Inhalers Lung - metabolism Lung Diseases - drug therapy Lung Diseases - microbiology Microscopy, Electron, Scanning Particle Size Powders Spray-drying Tissue Distribution Tobramycin Tobramycin - administration & dosage Tobramycin - pharmacokinetics X-Ray Diffraction
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