Chloroaluminium phthalocyanine polymeric nanoparticles as photosensitisers: Photophysical and physicochemical characterisation, release and phototoxicity in vitro

[Display omitted] Nanoparticles of poly(d,l-lactide-co-glycolide), poly(d,l-lactide) and polyethylene glycol-block-poly(d,l-lactide) were developed to encapsulate chloroaluminium phthalocyanine (AlClPc), a new hydrophobic photosensitiser used in photodynamic therapy (PDT). The mean nanoparticle size...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2013-06, Vol.49 (3), p.371-381
Hauptverfasser:	de Paula, Carina Silva, Tedesco, Antonio Cláudio, Primo, Fernando Lucas, Vilela, José Mário Carneiro, Andrade, Margareth Spangler, Mosqueira, Vanessa Carla Furtado
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Cells, Cultured Chloroaluminium phthalocyanine Fibroblasts - drug effects Humans Indoles - administration & dosage Indoles - chemistry Microscopy, Atomic Force Nanocapsules - administration & dosage Nanocapsules - chemistry Nanospheres - administration & dosage Nanospheres - chemistry Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Photodynamic therapy Photophysical characterisation Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Phototoxicity in vitro Polymeric nanoparticles Polymers - administration & dosage Polymers - chemistry Release kinetic Solubility
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