Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists

To further investigate the structure-activity relationship (SAR) of the 5-hydroxytryptamine type 6 (5-HT6) receptor agonist 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (EMD386088, 6), a series of 2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized, and in vitro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2013-05, Vol.63, p.578-588
Hauptverfasser:	Mattsson, Cecilia, Svensson, Peder, Boettcher, Henning, Sonesson, Clas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Cell Line HEK293 Cells HeLa Cells Humans Hydrogen Bonding Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Models, Chemical Models, Molecular Molecular Conformation Molecular Structure Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Receptor Agonists - chemical synthesis Serotonin Receptor Agonists - chemistry Serotonin Receptor Agonists - pharmacology Structure-Activity Relationship Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!