Synthesis, in vitro antitumor evaluation and DNA-binding study of novel tetrahydroquinolines and some derived tricyclic and tetracyclic ring systems

The synthesis of some new tetrahydroquinolines, tetrahydropyrimido[4,5-b]quinolines, and tetrahydropentaazacyclopenta[a]anthracenes structurally related to some DNA intercalators is described. Fifteen compounds were evaluated for their antitumor activity by the National Cancer Institute (NCI), in vi...

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Veröffentlicht in:	European journal of medicinal chemistry 2013-05, Vol.63, p.133-143
Hauptverfasser:	Faidallah, Hassan M., Rostom, Sherif A.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antitumor activity Binding, Competitive Cell Line, Tumor Cell Survival - drug effects DNA - chemistry DNA - metabolism DNA-binding Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HCT116 Cells Heterocyclic Compounds, 3-Ring - chemistry Heterocyclic Compounds, 3-Ring - metabolism Heterocyclic Compounds, 3-Ring - pharmacology Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - metabolism Heterocyclic Compounds, 4 or More Rings - pharmacology HL-60 Cells HT29 Cells Humans K562 Cells MCF-7 Cells Molecular Structure Quinolines - chemistry Quinolines - metabolism Quinolines - pharmacology Structure-Activity Relationship Tetrahydropyrimido[4,5-b]quinolines Tetrahydroquinolines
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