EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

The mesenchymal-epithelial transition factor (c-Met) receptor, also known as hepatocyte growth factor receptor (HGFR), controls morphogenesis, a process that is physiologically required for embryonic development and tissue repair. Aberrant c-Met activation is associated with a variety of human malig...

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Veröffentlicht in:	Clinical cancer research 2013-06, Vol.19 (11), p.2941-2951
Hauptverfasser:	BLADT, Friedhelm, FADEN, Bettina, PEHL, Ulrich, STIEBER, Frank, SCHADT, Oliver, BLAUKAT, Andree, FRIESE-HAMIM, Manja, KNUEHL, Christine, WILM, Claudia, FITTSCHEN, Claus, GRÄDLER, Ulrich, MEYRING, Michael, DORSCH, Dieter, JAEHRLING, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Humans Medical sciences Mice Morpholines - pharmacology Pharmacology. Drug treatments Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-met - antagonists & inhibitors Pyridazines - administration & dosage Pyridazines - pharmacology Pyrimidines - administration & dosage Pyrimidines - pharmacology Signal Transduction - drug effects Xenograft Model Antitumor Assays
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