Large-conductance Ca²⁺-activated potassium channel in mitochondria of endothelial EA.hy926 cells

In the present study, we describe the existence of a large-conductance Ca²⁺-activated potassium (BKCa) channel in the mitochondria of the human endothelial cell line EA.hy926. A single-channel current was recorded from endothelial mitoplasts (i.e., inner mitochondrial membrane) using the patch-clamp...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2013-06, Vol.304 (11), p.H1415-H1427
Hauptverfasser:	Bednarczyk, Piotr, Koziel, Agnieszka, Jarmuszkiewicz, Wieslawa, Szewczyk, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - pharmacology Blotting, Western Cells, Cultured Electrophoresis, Polyacrylamide Gel Endothelium - cytology Endothelium - metabolism Energy Metabolism - physiology Fluorescent Dyes Humans Large-Conductance Calcium-Activated Potassium Channels - drug effects Large-Conductance Calcium-Activated Potassium Channels - metabolism Membrane Potential, Mitochondrial - physiology Mitochondria, Heart - metabolism Myocardium - metabolism Oxygen Consumption - physiology Patch-Clamp Techniques Peptides - pharmacology Potassium Channel Blockers - pharmacology
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