Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
•We studied the role of mPFC in inhibitory avoidance (IA) memory processing.•mPFC is necessary to IA memory acquisition and consolidation.•mPFC is necessary to IA memory retrieval of both recent and remote memories. The neocortex is thought to be a distributed learning system that gradually integrat...
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| Veröffentlicht in: | Neurobiology of learning and memory 2013-07, Vol.103, p.19-25 |
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| container_title | Neurobiology of learning and memory |
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| creator | Gonzalez, Carolina Kramar, Cecilia Garagoli, Fernando Rossato, Janine I. Weisstaub, Noelia Cammarota, Martín Medina, Jorge H. |
| description | •We studied the role of mPFC in inhibitory avoidance (IA) memory processing.•mPFC is necessary to IA memory acquisition and consolidation.•mPFC is necessary to IA memory retrieval of both recent and remote memories.
The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase. |
| doi_str_mv | 10.1016/j.nlm.2013.04.006 |
| format | Article |
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The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.</description><identifier>ISSN: 1074-7427</identifier><identifier>EISSN: 1095-9564</identifier><identifier>DOI: 10.1016/j.nlm.2013.04.006</identifier><identifier>PMID: 23608181</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amygdala - drug effects ; Amygdala - physiology ; Animals ; Anisomycin - pharmacology ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Cognition & reasoning ; Emetine - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Inhibitory avoidance ; Learning ; Male ; Medial prefrontal cortex ; Memory ; Memory - drug effects ; Memory - physiology ; Memory consolidation ; Memory retrieval ; Muscimol - pharmacology ; Nerve Net - drug effects ; Nerve Net - physiology ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar</subject><ispartof>Neurobiology of learning and memory, 2013-07, Vol.103, p.19-25</ispartof><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-7a29c35e6a8571595392d0a80bfcc35e1b6ed71d0620cf4fde9fb00045a524b53</citedby><cites>FETCH-LOGICAL-c454t-7a29c35e6a8571595392d0a80bfcc35e1b6ed71d0620cf4fde9fb00045a524b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nlm.2013.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27520335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23608181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez, Carolina</creatorcontrib><creatorcontrib>Kramar, Cecilia</creatorcontrib><creatorcontrib>Garagoli, Fernando</creatorcontrib><creatorcontrib>Rossato, Janine I.</creatorcontrib><creatorcontrib>Weisstaub, Noelia</creatorcontrib><creatorcontrib>Cammarota, Martín</creatorcontrib><creatorcontrib>Medina, Jorge H.</creatorcontrib><title>Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories</title><title>Neurobiology of learning and memory</title><addtitle>Neurobiol Learn Mem</addtitle><description>•We studied the role of mPFC in inhibitory avoidance (IA) memory processing.•mPFC is necessary to IA memory acquisition and consolidation.•mPFC is necessary to IA memory retrieval of both recent and remote memories.
The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.</description><subject>Amygdala - drug effects</subject><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Anisomycin - pharmacology</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cognition & reasoning</subject><subject>Emetine - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Inhibitory avoidance</subject><subject>Learning</subject><subject>Male</subject><subject>Medial prefrontal cortex</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Memory consolidation</subject><subject>Memory retrieval</subject><subject>Muscimol - pharmacology</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiology</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Inhibitory avoidance</topic><topic>Learning</topic><topic>Male</topic><topic>Medial prefrontal cortex</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Memory consolidation</topic><topic>Memory retrieval</topic><topic>Muscimol - pharmacology</topic><topic>Nerve Net - drug effects</topic><topic>Nerve Net - physiology</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez, Carolina</creatorcontrib><creatorcontrib>Kramar, Cecilia</creatorcontrib><creatorcontrib>Garagoli, Fernando</creatorcontrib><creatorcontrib>Rossato, Janine I.</creatorcontrib><creatorcontrib>Weisstaub, Noelia</creatorcontrib><creatorcontrib>Cammarota, Martín</creatorcontrib><creatorcontrib>Medina, Jorge H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of learning and memory</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez, Carolina</au><au>Kramar, Cecilia</au><au>Garagoli, Fernando</au><au>Rossato, Janine I.</au><au>Weisstaub, Noelia</au><au>Cammarota, Martín</au><au>Medina, Jorge H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories</atitle><jtitle>Neurobiology of learning and memory</jtitle><addtitle>Neurobiol Learn Mem</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>103</volume><spage>19</spage><epage>25</epage><pages>19-25</pages><issn>1074-7427</issn><eissn>1095-9564</eissn><abstract>•We studied the role of mPFC in inhibitory avoidance (IA) memory processing.•mPFC is necessary to IA memory acquisition and consolidation.•mPFC is necessary to IA memory retrieval of both recent and remote memories.
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| subjects | Amygdala - drug effects Amygdala - physiology Animals Anisomycin - pharmacology Avoidance Learning - drug effects Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Brain Cognition & reasoning Emetine - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology Inhibitory avoidance Learning Male Medial prefrontal cortex Memory Memory - drug effects Memory - physiology Memory consolidation Memory retrieval Muscimol - pharmacology Nerve Net - drug effects Nerve Net - physiology Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar |
| title | Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories |
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