Antitumor and immunomodulatory activity of a polysaccharide from fungus Coprinus comatus (Mull.:Fr.) Gray

In our study, a water-soluble polysaccharide (CCPa-1) was successfully purified from the fruiting bodies of Coprinus comatus by DEAE-cellulose and Sepharose CL-6B column chromatography. The molecular weight was evaluated to be 53.6 kDa as determined by high performance size exclusion chromatography...

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Veröffentlicht in:	International journal of biological macromolecules 2013-07, Vol.58, p.349-353
Hauptverfasser:	Jiang, Xiao-Gang, Lian, Ming-Xue, Han, Yan, Lv, She-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Coprinus - chemistry Fungal Polysaccharides - isolation & purification Fungal Polysaccharides - pharmacology Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Interleukin-2 - blood Male Mice Mice, Inbred ICR Sarcoma, Experimental - drug therapy Sarcoma, Experimental - immunology Sarcoma, Experimental - pathology Spleen - drug effects Spleen - pathology Tumor Necrosis Factor-alpha - blood
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