Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia
Summary It has been reported that patients with a single MEG spike cluster have better postoperative outcomes compared to patients with multiple clusters. However, the problem of identifying a genuine source in the multiple MEG spike clusters remains unsolved. The aim of this study was to determine...
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| Veröffentlicht in: | Epilepsy research 2013-07, Vol.105 (1), p.118-124 |
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| description | Summary It has been reported that patients with a single MEG spike cluster have better postoperative outcomes compared to patients with multiple clusters. However, the problem of identifying a genuine source in the multiple MEG spike clusters remains unsolved. The aim of this study was to determine the focus of the epileptic activity in a situation with multiple MEG spike clusters. Five patients with intractable epilepsy with multiple MEG spike clusters were retrospectively investigated. They had pathologically proven type IA focal cortical dysplasia (FCD) with discordant multimodal presurgical evaluations, and showed a favorable postoperative outcome. MEG spikes were localized and clustered using a hierarchical clustering method. Then, effective connectivity (a phase-slope index method) referring to the causal interaction between distant structures in the brain was applied to the source waveforms extracted from the multiple MEG spike clusters. Finally, the information source, that is, the driver region between multiple clusters, could be identified. We found that 4 of the 5 FCD patients exhibited the driver regions were coincident with the resection area, which was also quite consistent at different epochs. Our results suggest that effective connectivity analysis has a potential value as a presurgical evaluation when multiple MEG spike clusters are found. |
| doi_str_mv | 10.1016/j.eplepsyres.2013.01.011 |
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However, the problem of identifying a genuine source in the multiple MEG spike clusters remains unsolved. The aim of this study was to determine the focus of the epileptic activity in a situation with multiple MEG spike clusters. Five patients with intractable epilepsy with multiple MEG spike clusters were retrospectively investigated. They had pathologically proven type IA focal cortical dysplasia (FCD) with discordant multimodal presurgical evaluations, and showed a favorable postoperative outcome. MEG spikes were localized and clustered using a hierarchical clustering method. Then, effective connectivity (a phase-slope index method) referring to the causal interaction between distant structures in the brain was applied to the source waveforms extracted from the multiple MEG spike clusters. Finally, the information source, that is, the driver region between multiple clusters, could be identified. We found that 4 of the 5 FCD patients exhibited the driver regions were coincident with the resection area, which was also quite consistent at different epochs. Our results suggest that effective connectivity analysis has a potential value as a presurgical evaluation when multiple MEG spike clusters are found.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2013.01.011</identifier><identifier>PMID: 23422686</identifier><identifier>CODEN: EPIRE8</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Action Potentials - physiology ; Adult ; Biological and medical sciences ; Cluster Analysis ; Drug toxicity and drugs side effects treatment ; Effective connectivity ; Electrodiagnosis. Electric activity recording ; Female ; Focal cortical dysplasia ; Follow-Up Studies ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Information source ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetoencephalography ; Magnetoencephalography - methods ; Male ; Malformations of Cortical Development - diagnosis ; Malformations of Cortical Development - physiopathology ; Malformations of Cortical Development - surgery ; Malformations of the nervous system ; Medical sciences ; Middle Aged ; Multiple spike clusters ; Nervous system ; Nervous system (semeiology, syndromes) ; Neurology ; Pharmacology. Drug treatments ; Retrospective Studies ; Toxicity: urogenital system ; Young Adult</subject><ispartof>Epilepsy research, 2013-07, Vol.105 (1), p.118-124</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-7cce344bce2809380f3aa7104f7869ca0bb68523ad7c2f4f7a2693318485f41e3</citedby><cites>FETCH-LOGICAL-c459t-7cce344bce2809380f3aa7104f7869ca0bb68523ad7c2f4f7a2693318485f41e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.eplepsyres.2013.01.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27434286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23422686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Seung-Hyun</creatorcontrib><creatorcontrib>Jeong, Woorim</creatorcontrib><creatorcontrib>Chung, Chun Kee</creatorcontrib><title>Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>Summary It has been reported that patients with a single MEG spike cluster have better postoperative outcomes compared to patients with multiple clusters. However, the problem of identifying a genuine source in the multiple MEG spike clusters remains unsolved. The aim of this study was to determine the focus of the epileptic activity in a situation with multiple MEG spike clusters. Five patients with intractable epilepsy with multiple MEG spike clusters were retrospectively investigated. They had pathologically proven type IA focal cortical dysplasia (FCD) with discordant multimodal presurgical evaluations, and showed a favorable postoperative outcome. MEG spikes were localized and clustered using a hierarchical clustering method. Then, effective connectivity (a phase-slope index method) referring to the causal interaction between distant structures in the brain was applied to the source waveforms extracted from the multiple MEG spike clusters. Finally, the information source, that is, the driver region between multiple clusters, could be identified. We found that 4 of the 5 FCD patients exhibited the driver regions were coincident with the resection area, which was also quite consistent at different epochs. Our results suggest that effective connectivity analysis has a potential value as a presurgical evaluation when multiple MEG spike clusters are found.</description><subject>Action Potentials - physiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cluster Analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Effective connectivity</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Female</subject><subject>Focal cortical dysplasia</subject><subject>Follow-Up Studies</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Information source</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetoencephalography</subject><subject>Magnetoencephalography - methods</subject><subject>Male</subject><subject>Malformations of Cortical Development - diagnosis</subject><subject>Malformations of Cortical Development - physiopathology</subject><subject>Malformations of Cortical Development - surgery</subject><subject>Malformations of the nervous system</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple spike clusters</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Toxicity: urogenital system</subject><subject>Young Adult</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktr3DAQgEVpaDZp_0LRpdCLt3qtLV8KbcgLEnpoexayPAJtbNnV2AH_-8jZbQM5FQYkhm9mxKchhHK25YyXX_ZbGDsYcUmAW8G43DKeg78hG64rUZRaqbdkw2rBCi44PyVniHvGWMWUekdOhVRClLrckOU2-iH1dgpDpDjMyQENkfZzN4U8gt5fXlMcwwNQ1804QULqbKRNplqIU_ABWtosFLwHN4XHzA0xPl_DtKyt_OBsl7NpCuulXXDsLAb7npx42yF8OJ7n5PfV5a-Lm-Lux_Xtxbe7wqldPRWVcyCVahwIzWqpmZfWVpwpX-mydpY1Tal3Qtq2csLnrBVlLSXXSu-84iDPyedD3zENf2bAyfQBHXSdjTDMaLgsVcV0vSszqg-oSwNiAm_GFHqbFsOZWcWbvXkRb1bxhvEcPJd-PE6Zmx7af4V_TWfg0xGwmD34ZKML-MJVKpPP3PcDB9nJY4Bk0AWIDtqQslbTDuF_XvP1VRPXhbj6f4AFcJ__OWbnhhsUhpmf66Kse8Jl3hGpK_kEOYi9Ig</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Jin, Seung-Hyun</creator><creator>Jeong, Woorim</creator><creator>Chung, Chun Kee</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia</title><author>Jin, Seung-Hyun ; Jeong, Woorim ; Chung, Chun Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-7cce344bce2809380f3aa7104f7869ca0bb68523ad7c2f4f7a2693318485f41e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Action Potentials - physiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cluster Analysis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Effective connectivity</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Female</topic><topic>Focal cortical dysplasia</topic><topic>Follow-Up Studies</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Information source</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetoencephalography</topic><topic>Magnetoencephalography - methods</topic><topic>Male</topic><topic>Malformations of Cortical Development - diagnosis</topic><topic>Malformations of Cortical Development - physiopathology</topic><topic>Malformations of Cortical Development - surgery</topic><topic>Malformations of the nervous system</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple spike clusters</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Toxicity: urogenital system</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Seung-Hyun</creatorcontrib><creatorcontrib>Jeong, Woorim</creatorcontrib><creatorcontrib>Chung, Chun Kee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Seung-Hyun</au><au>Jeong, Woorim</au><au>Chung, Chun Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>105</volume><issue>1</issue><spage>118</spage><epage>124</epage><pages>118-124</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><coden>EPIRE8</coden><abstract>Summary It has been reported that patients with a single MEG spike cluster have better postoperative outcomes compared to patients with multiple clusters. However, the problem of identifying a genuine source in the multiple MEG spike clusters remains unsolved. The aim of this study was to determine the focus of the epileptic activity in a situation with multiple MEG spike clusters. Five patients with intractable epilepsy with multiple MEG spike clusters were retrospectively investigated. They had pathologically proven type IA focal cortical dysplasia (FCD) with discordant multimodal presurgical evaluations, and showed a favorable postoperative outcome. MEG spikes were localized and clustered using a hierarchical clustering method. Then, effective connectivity (a phase-slope index method) referring to the causal interaction between distant structures in the brain was applied to the source waveforms extracted from the multiple MEG spike clusters. Finally, the information source, that is, the driver region between multiple clusters, could be identified. 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| subjects | Action Potentials - physiology Adult Biological and medical sciences Cluster Analysis Drug toxicity and drugs side effects treatment Effective connectivity Electrodiagnosis. Electric activity recording Female Focal cortical dysplasia Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Information source Investigative techniques, diagnostic techniques (general aspects) Magnetoencephalography Magnetoencephalography - methods Male Malformations of Cortical Development - diagnosis Malformations of Cortical Development - physiopathology Malformations of Cortical Development - surgery Malformations of the nervous system Medical sciences Middle Aged Multiple spike clusters Nervous system Nervous system (semeiology, syndromes) Neurology Pharmacology. Drug treatments Retrospective Studies Toxicity: urogenital system Young Adult |
| title | Information source in multiple MEG spike clusters can be identified by effective connectivity in focal cortical dysplasia |
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