Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway

Abstract Pentoxifylline (PTX), a phosphodiesterase inhibitor, has been shown to have anti-metastatic or anti-angiogenic activity against many human cancers. However, the underlying mechanisms are unknown. In this study, we report that, PTX at sub-toxic doses can inhibit melanoma tumor growth and ang...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2013-06, Vol.67 (5), p.399-405
Hauptverfasser:	Kamran, Mohammad Zahid, Gude, Rajiv P
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Cell Line, Tumor Dose-Response Relationship, Drug Female Humans Internal Medicine Medical Education Melanoma Melanoma - drug therapy Melanoma - pathology Metastasis Mice Mice, Inbred NOD Mice, SCID Neovascularization, Physiologic - drug effects Pentoxifylline Pentoxifylline - administration & dosage Pentoxifylline - pharmacology Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - pharmacology Phosphorylation - drug effects Signal Transduction - drug effects Skin Neoplasms - drug therapy Skin Neoplasms - pathology STAT3 STAT3 Transcription Factor - metabolism Tumor Microenvironment - drug effects Xenograft Model Antitumor Assays
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