Enhanced Rho‐Associated Protein Kinase Activation in Patients With Systemic Lupus Erythematosus

Objective Rho‐associated protein kinases (ROCKs) have been implicated in the pathogenesis of cardiovascular and renal disorders. We recently showed that ROCKs could regulate the differentiation of murine Th17 cells and the production of interleukin‐17 (IL‐17) and IL‐21, two cytokines associated with...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-06, Vol.65 (6), p.1592-1602
Hauptverfasser:	Isgro, Josephine, Gupta, Sanjay, Jacek, Elzbieta, Pavri, Tanya, Duculan, Roland, Kim, Mimi, Kirou, Kyriakos A., Salmon, Jane E., Pernis, Alessandra B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Autoimmune diseases Blotting, Western CD4-Positive T-Lymphocytes - enzymology Cell Culture Techniques Cross-Sectional Studies Cytokines Enzyme-Linked Immunosorbent Assay Female Humans Kinases Lupus Lupus Erythematosus, Systemic - enzymology Lymphocytes Male Middle Aged rho-Associated Kinases - metabolism Th17 Cells - enzymology Th17 Cells - metabolism Young Adult
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