Potential radiosensitizing agents. 4. 2-Nitroimidazole nucleosides

A series of 2-nitroimidazole nucleoside analogues has been synthesized as potential radiosensitizers in an effort to reduce neurotoxicity and increase therapeutic efficacy. The 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl and glucothiopyranosyl analogues of 2-nitroimidazole were synthesized by conde...

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Veröffentlicht in:	J. Med. Chem.; (United States) 1982-11, Vol.25 (11), p.1339-1342
Hauptverfasser:	Sakaguchi, M, Webb, M W, Agrawal, K C
Format:	Artikel
Sprache:	eng
Schlagworte:	400300 - Organic Chemistry- (-1987) 550603 - Medicine- External Radiation in Therapy- (1980-) 560121 - Radiation Effects on Cells- External Source- (-1987) Animals ANOXIA AZOLES CELL CULTURES Cell Survival - drug effects Cells, Cultured Chemical Phenomena CHEMICAL PREPARATION Chemistry, Physical Cricetinae Cricetulus DRUGS Gamma Rays HETEROCYCLIC COMPOUNDS IMIDAZOLES INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY Nitroimidazoles - chemical synthesis Nitroimidazoles - pharmacology ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Sensitizing Agents - chemical synthesis RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY RADIOSENSITIVITY EFFECTS RADIOSENSITIZERS SYNTHESIS TOXICITY
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