Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis

Mastitis is an inflammatory disease caused by microbial infection. Staphylococcus aureus is the major etiological microorganism responsible for both clinical and subclinical mastitis in dairy cows. A mouse model of S. aureus mastitis is available. Baicalin is isolated from Scutellaria and is known t...

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Veröffentlicht in:	International immunopharmacology 2013-06, Vol.16 (2), p.125-130
Hauptverfasser:	Guo, Mengyao, Zhang, Naisheng, Li, Depeng, Liang, Dejie, Liu, Zhicheng, Li, Fenyang, Fu, Yunhe, Cao, Yongguo, Deng, Xuming, Yang, Zhengtao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammation Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Baicalin Cytokines - metabolism Female Flavonoids - pharmacology Flavonoids - therapeutic use Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mastitis - drug therapy Mastitis - metabolism Mastitis - pathology Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Nuclear factor-kappaB (NF-κB) p38 Phosphorylation - drug effects S. aureus mastitis Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Staphylococcal Infections - pathology Staphylococcus aureus
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