Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer

BACKGROUND Evidence shows that angiotensin II type 1 receptor (AT1R) blockers may be associated with improved outcome in prostate cancer patients. It has been proposed that part of this effect could be due to angiotensin II type 2 receptor (AT2R) activation, the only active angiotensin II receptor i...

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Veröffentlicht in:	The Prostate 2013-07, Vol.73 (10), p.1057-1068
Hauptverfasser:	Guimond, Marie-Odile, Battista, Marie-Claude, Nikjouitavabi, Fatemeh, Carmel, Maude, Barres, Véronique, Doueik, Alexandre A., Fazli, Ladan, Gleave, Martin, Sabbagh, Robert, Gallo-Payet, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use AT2 receptor cancer Cell Proliferation - drug effects human prostate Humans Losartan - pharmacology Losartan - therapeutic use Male primary cell culture proliferation Prostate - drug effects Prostate - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Receptor, Angiotensin, Type 2 - agonists Receptor, Angiotensin, Type 2 - metabolism Tissue Array Analysis Tumor Suppressor Proteins - metabolism
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