ctDNA binding affinity and in vitro antitumor activity of three Keggin type polyoxotungestates

•The POMs bind to ct-DNA via groove or outside stacking mode.•POMs have an intense inhibitory effect on the growth of MCF-7 and HEK-293 cancer cells.•The binding affinity of POMs to ctDNA is highly depended to their metal substituted.•CoWCpFe showed the highest antitumor activity in vitro. The ctDNA...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2013-07, Vol.124, p.27-33
Hauptverfasser:	Dianat, S., Bordbar, A.K., Tangestaninejad, S., Yadollahi, B., Zarkesh-Esfahani, S.H., Habibi, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity binding capacity Calf thymus DNA Cell Line, Tumor cell membranes Cell Proliferation - drug effects DNA - chemistry DNA - metabolism electrostatic interactions Fluorescence fluorescence emission spectroscopy HEK293 Cells Humans MCF-7 Cells Models, Molecular neoplasm cells Organometallic Compounds - chemistry Organometallic Compounds - pharmacology photobiology photochemistry Polyoxometalates redox potential Spectrometry, Fluorescence UV–Vis Voltammetric method X-Ray Absorption Spectroscopy
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