Helical Oligomers of Thiazole-Based γ-Amino Acids: Synthesis and Structural Studies

9‐Helix: 4‐Amino(methyl)‐1,3‐thiazole‐5‐carboxylic acids (ATCs) were synthesized as new γ‐amino acid building blocks. The structures of various ATC oligomers were analyzed in solution by CD and NMR spectroscopy and in the solid state by X‐ray crystallography. The ATC sequences adopted a well‐defined...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-06, Vol.52 (23), p.6006-6010
Hauptverfasser:	Mathieu, Loïc, Legrand, Baptiste, Deng, Cheng, Vezenkov, Lubomir, Wenger, Emmanuel, Didierjean, Claude, Amblard, Muriel, Averlant-Petit, Marie-Christine, Masurier, Nicolas, Lisowski, Vincent, Martinez, Jean, Maillard, Ludovic T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Circular Dichroism conformation analysis foldamers helical structures Models, Molecular peptidomimetics Polymers - chemistry Thiazoles - chemical synthesis Thiazoles - chemistry γ-peptides
Online-Zugang:	Volltext
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