Enhancement and depression by inosine of the growth inhibitory action of 5-fluorouracil on cultured Jensen tumor cells

Continuous exposure of Jensen tumor cells in vitro to 1 mM inosine following a 1 hr exposure to 5-fluorouracil resulted in a 5-fold potentiation of growth inhibition. This effect was abolished by the simultaneous presence of 1 mM cytidine and was attributable to altered metabolic processing of drug...

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Veröffentlicht in:	Biochemical and biophysical research communications 1983-04, Vol.112 (1), p.235-241
Hauptverfasser:	Beltz, Richard E., Waters, Robert N., Hegarty, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cells, Cultured Cytidine - pharmacology Drug Synergism Fluorouracil - antagonists & inhibitors Fluorouracil - pharmacology Inosine - pharmacology Neoplasms, Experimental - metabolism Rats
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