Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks
Despite the development of consensus-based frameworks to define cancer cachexia, the validity and usefulness of these frameworks are relatively unknown. The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III non-small-cell lung carcinoma (NSCLC...
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| Veröffentlicht in: | British journal of nutrition 2013-06, Vol.109 (12), p.2231-2239 |
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| creator | van der Meij, Barbara S. Schoonbeek, Coline P. Smit, Egbert F. Muscaritoli, Maurizio van Leeuwen, Paul A. M. Langius, Jacqueline A. E. |
| description | Despite the development of consensus-based frameworks to define cancer cachexia, the validity and usefulness of these frameworks are relatively unknown. The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III non-small-cell lung carcinoma (NSCLC) by using a cancer-specific framework and a general framework for cachexia, and to explore the prognostic value of pre-cachexia and cachexia. In forty patients at diagnosis of stage III NSCLC, weight loss, fat-free mass, handgrip strength, anorexia and serum biochemistry, assessed before the first chemotherapy, were used to define ‘cancer cachexia’ or ‘cachexia’. The cancer-specific framework also classified for pre-cachexia and refractory cachexia. Additionally, quality of life was assessed by the European Organisation for Research and Treatment of Cancer – Quality of Life Questionnaire C30. Groups were compared using independent t tests, ANOVA, Kaplan–Meier and Cox survival analyses. Based on the cancer-specific framework, pre-cachexia was present in nine patients (23 %) and cancer cachexia was present in seven patients (18 %). Cancer cachexia was associated with a reduced quality of life (P= 0·03) and shorter survival (hazard ratio (HR) = 2·9; P= 0·04). When using the general framework, cachexia was present in eleven patients (28 %), and was associated with a reduced quality of life (P= 0·08) and shorter survival (HR = 4·4; P= 0·001). In conclusion, pre-cachexia and cachexia are prevalent in this small population of patients at diagnosis of stage III NSCLC. For both frameworks, cachexia appears to be associated with a reduced quality of life and shorter survival. Further studies are warranted to more extensively explore the validity and prognostic value of these new frameworks in cancer patients. |
| doi_str_mv | 10.1017/S0007114512004527 |
| format | Article |
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M. ; Langius, Jacqueline A. E.</creator><creatorcontrib>van der Meij, Barbara S. ; Schoonbeek, Coline P. ; Smit, Egbert F. ; Muscaritoli, Maurizio ; van Leeuwen, Paul A. M. ; Langius, Jacqueline A. E.</creatorcontrib><description>Despite the development of consensus-based frameworks to define cancer cachexia, the validity and usefulness of these frameworks are relatively unknown. The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III non-small-cell lung carcinoma (NSCLC) by using a cancer-specific framework and a general framework for cachexia, and to explore the prognostic value of pre-cachexia and cachexia. In forty patients at diagnosis of stage III NSCLC, weight loss, fat-free mass, handgrip strength, anorexia and serum biochemistry, assessed before the first chemotherapy, were used to define ‘cancer cachexia’ or ‘cachexia’. The cancer-specific framework also classified for pre-cachexia and refractory cachexia. Additionally, quality of life was assessed by the European Organisation for Research and Treatment of Cancer – Quality of Life Questionnaire C30. Groups were compared using independent t tests, ANOVA, Kaplan–Meier and Cox survival analyses. Based on the cancer-specific framework, pre-cachexia was present in nine patients (23 %) and cancer cachexia was present in seven patients (18 %). Cancer cachexia was associated with a reduced quality of life (P= 0·03) and shorter survival (hazard ratio (HR) = 2·9; P= 0·04). When using the general framework, cachexia was present in eleven patients (28 %), and was associated with a reduced quality of life (P= 0·08) and shorter survival (HR = 4·4; P= 0·001). In conclusion, pre-cachexia and cachexia are prevalent in this small population of patients at diagnosis of stage III NSCLC. For both frameworks, cachexia appears to be associated with a reduced quality of life and shorter survival. Further studies are warranted to more extensively explore the validity and prognostic value of these new frameworks in cancer patients.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114512004527</identifier><identifier>PMID: 23153477</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biological and medical sciences ; Cachexia - classification ; Cachexia - diagnosis ; Cachexia - etiology ; Carcinoma, Non-Small-Cell Lung - complications ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Eating disorders ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Human and Clinical Nutrition ; Humans ; Kaplan-Meier Estimate ; Lung cancer ; Male ; Medical sciences ; Metabolic syndrome ; Middle Aged ; Multiple tumors. 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Tumors in childhood (general aspects) ; Neoplasm Staging ; Nutrition research ; Pneumology ; Prognosis ; Proportional Hazards Models ; Quality of Life ; Retrospective Studies ; Survival ; Tumors ; Tumors of the respiratory system and mediastinum ; Variance analysis ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight</subject><ispartof>British journal of nutrition, 2013-06, Vol.109 (12), p.2231-2239</ispartof><rights>Copyright © The Authors 2012</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-8290a551d17c6ee875e8951c8d8b135ffba3e36797f9fb2467a6b78444b406413</citedby><cites>FETCH-LOGICAL-c512t-8290a551d17c6ee875e8951c8d8b135ffba3e36797f9fb2467a6b78444b406413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114512004527/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27397692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23153477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Meij, Barbara S.</creatorcontrib><creatorcontrib>Schoonbeek, Coline P.</creatorcontrib><creatorcontrib>Smit, Egbert F.</creatorcontrib><creatorcontrib>Muscaritoli, Maurizio</creatorcontrib><creatorcontrib>van Leeuwen, Paul A. M.</creatorcontrib><creatorcontrib>Langius, Jacqueline A. E.</creatorcontrib><title>Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Despite the development of consensus-based frameworks to define cancer cachexia, the validity and usefulness of these frameworks are relatively unknown. The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III non-small-cell lung carcinoma (NSCLC) by using a cancer-specific framework and a general framework for cachexia, and to explore the prognostic value of pre-cachexia and cachexia. In forty patients at diagnosis of stage III NSCLC, weight loss, fat-free mass, handgrip strength, anorexia and serum biochemistry, assessed before the first chemotherapy, were used to define ‘cancer cachexia’ or ‘cachexia’. The cancer-specific framework also classified for pre-cachexia and refractory cachexia. Additionally, quality of life was assessed by the European Organisation for Research and Treatment of Cancer – Quality of Life Questionnaire C30. Groups were compared using independent t tests, ANOVA, Kaplan–Meier and Cox survival analyses. Based on the cancer-specific framework, pre-cachexia was present in nine patients (23 %) and cancer cachexia was present in seven patients (18 %). Cancer cachexia was associated with a reduced quality of life (P= 0·03) and shorter survival (hazard ratio (HR) = 2·9; P= 0·04). When using the general framework, cachexia was present in eleven patients (28 %), and was associated with a reduced quality of life (P= 0·08) and shorter survival (HR = 4·4; P= 0·001). In conclusion, pre-cachexia and cachexia are prevalent in this small population of patients at diagnosis of stage III NSCLC. For both frameworks, cachexia appears to be associated with a reduced quality of life and shorter survival. Further studies are warranted to more extensively explore the validity and prognostic value of these new frameworks in cancer patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cachexia - classification</subject><subject>Cachexia - diagnosis</subject><subject>Cachexia - etiology</subject><subject>Carcinoma, Non-Small-Cell Lung - complications</subject><subject>Carcinoma, Non-Small-Cell Lung - physiopathology</subject><subject>Eating disorders</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Staging</subject><subject>Nutrition research</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Survival</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Variance analysis</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kd2KFDEQhYMo7uzqA3gjARH2Jpp056fjnSz-DCwoqNdNdTo9Zu1OxlQ3u_MWPrJpdnRF8SoU9Z1TVTmEPBH8heDCvPzEOTdCSCUqzqWqzD2yEdIoVmld3Sebtc3W_gk5RbwqZSO4fUhOqlqoWhqzIT8-Zs8cuK_-JgCF2NO7YqZ9gF1MGJCmgeIMO0-32y2NKTKcYByZ8-NIxyXuiiy7ENMEr4oL9Tf7MWWYUz4U3dIfqEvTHnIo5HydShXRR1yQdYC-p0OGyV-n_A0fkQcDjOgfH98z8uXtm88X79nlh3fbi9eXzJVrZ9ZUloNSohfGae8bo3xjlXBN33SiVsPQQe1rbawZ7NBVUhvQnWmklJ3kWor6jJzf-u5z-r54nNsp4HoORJ8WbIuJtkoqZQr67C_0Ki05lu1WSlmjjJSFEreUywkx-6Hd5zBBPrSCt2tc7T9xFc3To_PSTb7_rfiVTwGeHwFAB2P5pugC3nGmtkbbqnD1cThMXQ79zv-x43_H_wQdyKxR</recordid><startdate>20130628</startdate><enddate>20130628</enddate><creator>van der Meij, Barbara S.</creator><creator>Schoonbeek, Coline P.</creator><creator>Smit, Egbert F.</creator><creator>Muscaritoli, Maurizio</creator><creator>van Leeuwen, Paul A. 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M.</au><au>Langius, Jacqueline A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2013-06-28</date><risdate>2013</risdate><volume>109</volume><issue>12</issue><spage>2231</spage><epage>2239</epage><pages>2231-2239</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Despite the development of consensus-based frameworks to define cancer cachexia, the validity and usefulness of these frameworks are relatively unknown. The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III non-small-cell lung carcinoma (NSCLC) by using a cancer-specific framework and a general framework for cachexia, and to explore the prognostic value of pre-cachexia and cachexia. In forty patients at diagnosis of stage III NSCLC, weight loss, fat-free mass, handgrip strength, anorexia and serum biochemistry, assessed before the first chemotherapy, were used to define ‘cancer cachexia’ or ‘cachexia’. The cancer-specific framework also classified for pre-cachexia and refractory cachexia. Additionally, quality of life was assessed by the European Organisation for Research and Treatment of Cancer – Quality of Life Questionnaire C30. Groups were compared using independent t tests, ANOVA, Kaplan–Meier and Cox survival analyses. Based on the cancer-specific framework, pre-cachexia was present in nine patients (23 %) and cancer cachexia was present in seven patients (18 %). Cancer cachexia was associated with a reduced quality of life (P= 0·03) and shorter survival (hazard ratio (HR) = 2·9; P= 0·04). When using the general framework, cachexia was present in eleven patients (28 %), and was associated with a reduced quality of life (P= 0·08) and shorter survival (HR = 4·4; P= 0·001). In conclusion, pre-cachexia and cachexia are prevalent in this small population of patients at diagnosis of stage III NSCLC. For both frameworks, cachexia appears to be associated with a reduced quality of life and shorter survival. Further studies are warranted to more extensively explore the validity and prognostic value of these new frameworks in cancer patients.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23153477</pmid><doi>10.1017/S0007114512004527</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Cachexia - classification Cachexia - diagnosis Cachexia - etiology Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - physiopathology Eating disorders Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Human and Clinical Nutrition Humans Kaplan-Meier Estimate Lung cancer Male Medical sciences Metabolic syndrome Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging Nutrition research Pneumology Prognosis Proportional Hazards Models Quality of Life Retrospective Studies Survival Tumors Tumors of the respiratory system and mediastinum Variance analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight |
| title | Pre-cachexia and cachexia at diagnosis of stage III non-small-cell lung carcinoma: an exploratory study comparing two consensus-based frameworks |
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