Upgrading of Gleason score and prostate volume: a clinicopathological analysis
Objective To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading. Patient and Methods We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment. As a preoperative variable, we...
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| Veröffentlicht in: | BJU international 2013-06, Vol.111 (8), p.1310-1316 |
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| creator | Kim, Kwang Hyun Lim, Sey Kiat Shin, Tae‐Young Lee, Joo Yong Chung, Byung Ha Rha, Koon Ho Hong, Sung Joon |
| description | Objective
To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading.
Patient and Methods
We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment.
As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading.
To evaluate the association between prostate volume and GS upgrading, we developed multivariate models with volumetric pathological variables, including postoperative tumour volume and percent tumour volume (tumour volume as a percentage of prostate volume).
Results
GS upgrading was observed in 194 patients (43.0%).
As a preoperative variable, smaller prostate volume was an independent predictor of GS upgrading.
In regression analysis, prostate volume and postoperative tumour volume were inversely correlated.
On multivariate analysis including volumetric pathological variables, tumour volume was a strong independent factor influencing GS upgrading, and prostate volume lost statistical significance after adjusting for tumour volume.
Percent tumour volume was inversely correlated with GS upgrading after adjusting for tumour volume.
Conclusions
Smaller prostate volume was an independent predictor of GS upgrading as a preoperative variable.
The inverse relationship between prostate volume and GS upgrading seems to be attributable to cancer biology, which was represented by tumour volume in our study. Percent tumour volume was also inversely associated with GS upgrading.
These results suggest that biological factors and sampling error both play important roles in GS upgrading. |
| doi_str_mv | 10.1111/j.1464-410X.2013.11799.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1356954048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3911928961</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3249-7280c03f9d5b4f11886f178057f433d2290324c814bdc7ee31addc0e27899273</originalsourceid><addsrcrecordid>eNpdkctKAzEUhoMo3l9BAiK4ac11MnEhaPFK0U0FdyHNZGpKOhknHW3f3kxbFcwmh3M-wn_yAQAx6uN0LqZ9zDLWYxi99QnCNHWFlP3FFtj_HWz_1Ehme-AgxilCqZHxXbBHKOMEY74Pnl_rSaMLV01gKOG9tzqGCkYTGgt1VcC6CXGu5xZ-Bt_O7CXU0HhXORNqPX8PPkyc0T6h2i-ji0dgp9Q-2uPNfQhGd7ejwUNv-HL_OLge9mpKmOwJkiODaCkLPmYlxnmelVjkiIuSUVoQIlHiTI7ZuDDCWop1URhkicilJIIegvP1syneR2vjXM1cNNZ7XdnQRoUpzyRniOUJPf2HTkPbpLiJEpwSibnkiTrZUO14ZgtVN26mm6X6-agEnG0AHdPCZaMr4-IfJ6gUIuuSXa25L-ft8neOkerEqanqnKjOj-rEqZU4tVA3T6-rkn4DvbCJ-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753291595</pqid></control><display><type>article</type><title>Upgrading of Gleason score and prostate volume: a clinicopathological analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kim, Kwang Hyun ; Lim, Sey Kiat ; Shin, Tae‐Young ; Lee, Joo Yong ; Chung, Byung Ha ; Rha, Koon Ho ; Hong, Sung Joon</creator><creatorcontrib>Kim, Kwang Hyun ; Lim, Sey Kiat ; Shin, Tae‐Young ; Lee, Joo Yong ; Chung, Byung Ha ; Rha, Koon Ho ; Hong, Sung Joon</creatorcontrib><description>Objective
To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading.
Patient and Methods
We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment.
As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading.
To evaluate the association between prostate volume and GS upgrading, we developed multivariate models with volumetric pathological variables, including postoperative tumour volume and percent tumour volume (tumour volume as a percentage of prostate volume).
Results
GS upgrading was observed in 194 patients (43.0%).
As a preoperative variable, smaller prostate volume was an independent predictor of GS upgrading.
In regression analysis, prostate volume and postoperative tumour volume were inversely correlated.
On multivariate analysis including volumetric pathological variables, tumour volume was a strong independent factor influencing GS upgrading, and prostate volume lost statistical significance after adjusting for tumour volume.
Percent tumour volume was inversely correlated with GS upgrading after adjusting for tumour volume.
Conclusions
Smaller prostate volume was an independent predictor of GS upgrading as a preoperative variable.
The inverse relationship between prostate volume and GS upgrading seems to be attributable to cancer biology, which was represented by tumour volume in our study. Percent tumour volume was also inversely associated with GS upgrading.
These results suggest that biological factors and sampling error both play important roles in GS upgrading.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2013.11799.x</identifier><identifier>PMID: 23452115</identifier><identifier>CODEN: BJINFO</identifier><language>eng</language><publisher>Oxford: Wiley-Blackwell</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Androgens ; Biological and medical sciences ; Biopsy, Needle ; Disease Progression ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Multivariate analysis ; neoplasm grading ; Neoplasm Grading - methods ; Neoplasm Grading - trends ; Nephrology. Urinary tract diseases ; Prostate ; Prostate - pathology ; Prostatectomy ; prostatectomy (Mesh) ; prostatic neoplasm ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies ; Tumor Burden ; Tumors ; Tumors of the urinary system ; tumour burden ; Urinary tract. Prostate gland</subject><ispartof>BJU international, 2013-06, Vol.111 (8), p.1310-1316</ispartof><rights>2013 BJU International</rights><rights>2014 INIST-CNRS</rights><rights>2013 BJU International.</rights><rights>BJUI © 2013 BJU International</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2013.11799.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2013.11799.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27397767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23452115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Kwang Hyun</creatorcontrib><creatorcontrib>Lim, Sey Kiat</creatorcontrib><creatorcontrib>Shin, Tae‐Young</creatorcontrib><creatorcontrib>Lee, Joo Yong</creatorcontrib><creatorcontrib>Chung, Byung Ha</creatorcontrib><creatorcontrib>Rha, Koon Ho</creatorcontrib><creatorcontrib>Hong, Sung Joon</creatorcontrib><title>Upgrading of Gleason score and prostate volume: a clinicopathological analysis</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Objective
To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading.
Patient and Methods
We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment.
As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading.
To evaluate the association between prostate volume and GS upgrading, we developed multivariate models with volumetric pathological variables, including postoperative tumour volume and percent tumour volume (tumour volume as a percentage of prostate volume).
Results
GS upgrading was observed in 194 patients (43.0%).
As a preoperative variable, smaller prostate volume was an independent predictor of GS upgrading.
In regression analysis, prostate volume and postoperative tumour volume were inversely correlated.
On multivariate analysis including volumetric pathological variables, tumour volume was a strong independent factor influencing GS upgrading, and prostate volume lost statistical significance after adjusting for tumour volume.
Percent tumour volume was inversely correlated with GS upgrading after adjusting for tumour volume.
Conclusions
Smaller prostate volume was an independent predictor of GS upgrading as a preoperative variable.
The inverse relationship between prostate volume and GS upgrading seems to be attributable to cancer biology, which was represented by tumour volume in our study. Percent tumour volume was also inversely associated with GS upgrading.
These results suggest that biological factors and sampling error both play important roles in GS upgrading.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Androgens</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Disease Progression</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>neoplasm grading</subject><subject>Neoplasm Grading - methods</subject><subject>Neoplasm Grading - trends</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostate</subject><subject>Prostate - pathology</subject><subject>Prostatectomy</subject><subject>prostatectomy (Mesh)</subject><subject>prostatic neoplasm</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>tumour burden</subject><subject>Urinary tract. Prostate gland</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctKAzEUhoMo3l9BAiK4ac11MnEhaPFK0U0FdyHNZGpKOhknHW3f3kxbFcwmh3M-wn_yAQAx6uN0LqZ9zDLWYxi99QnCNHWFlP3FFtj_HWz_1Ehme-AgxilCqZHxXbBHKOMEY74Pnl_rSaMLV01gKOG9tzqGCkYTGgt1VcC6CXGu5xZ-Bt_O7CXU0HhXORNqPX8PPkyc0T6h2i-ji0dgp9Q-2uPNfQhGd7ejwUNv-HL_OLge9mpKmOwJkiODaCkLPmYlxnmelVjkiIuSUVoQIlHiTI7ZuDDCWop1URhkicilJIIegvP1syneR2vjXM1cNNZ7XdnQRoUpzyRniOUJPf2HTkPbpLiJEpwSibnkiTrZUO14ZgtVN26mm6X6-agEnG0AHdPCZaMr4-IfJ6gUIuuSXa25L-ft8neOkerEqanqnKjOj-rEqZU4tVA3T6-rkn4DvbCJ-Q</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Kim, Kwang Hyun</creator><creator>Lim, Sey Kiat</creator><creator>Shin, Tae‐Young</creator><creator>Lee, Joo Yong</creator><creator>Chung, Byung Ha</creator><creator>Rha, Koon Ho</creator><creator>Hong, Sung Joon</creator><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Upgrading of Gleason score and prostate volume: a clinicopathological analysis</title><author>Kim, Kwang Hyun ; Lim, Sey Kiat ; Shin, Tae‐Young ; Lee, Joo Yong ; Chung, Byung Ha ; Rha, Koon Ho ; Hong, Sung Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3249-7280c03f9d5b4f11886f178057f433d2290324c814bdc7ee31addc0e27899273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Androgens</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Disease Progression</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>neoplasm grading</topic><topic>Neoplasm Grading - methods</topic><topic>Neoplasm Grading - trends</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostate</topic><topic>Prostate - pathology</topic><topic>Prostatectomy</topic><topic>prostatectomy (Mesh)</topic><topic>prostatic neoplasm</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>tumour burden</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kwang Hyun</creatorcontrib><creatorcontrib>Lim, Sey Kiat</creatorcontrib><creatorcontrib>Shin, Tae‐Young</creatorcontrib><creatorcontrib>Lee, Joo Yong</creatorcontrib><creatorcontrib>Chung, Byung Ha</creatorcontrib><creatorcontrib>Rha, Koon Ho</creatorcontrib><creatorcontrib>Hong, Sung Joon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kwang Hyun</au><au>Lim, Sey Kiat</au><au>Shin, Tae‐Young</au><au>Lee, Joo Yong</au><au>Chung, Byung Ha</au><au>Rha, Koon Ho</au><au>Hong, Sung Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upgrading of Gleason score and prostate volume: a clinicopathological analysis</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2013-06</date><risdate>2013</risdate><volume>111</volume><issue>8</issue><spage>1310</spage><epage>1316</epage><pages>1310-1316</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><coden>BJINFO</coden><abstract>Objective
To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading.
Patient and Methods
We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment.
As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading.
To evaluate the association between prostate volume and GS upgrading, we developed multivariate models with volumetric pathological variables, including postoperative tumour volume and percent tumour volume (tumour volume as a percentage of prostate volume).
Results
GS upgrading was observed in 194 patients (43.0%).
As a preoperative variable, smaller prostate volume was an independent predictor of GS upgrading.
In regression analysis, prostate volume and postoperative tumour volume were inversely correlated.
On multivariate analysis including volumetric pathological variables, tumour volume was a strong independent factor influencing GS upgrading, and prostate volume lost statistical significance after adjusting for tumour volume.
Percent tumour volume was inversely correlated with GS upgrading after adjusting for tumour volume.
Conclusions
Smaller prostate volume was an independent predictor of GS upgrading as a preoperative variable.
The inverse relationship between prostate volume and GS upgrading seems to be attributable to cancer biology, which was represented by tumour volume in our study. Percent tumour volume was also inversely associated with GS upgrading.
These results suggest that biological factors and sampling error both play important roles in GS upgrading.</abstract><cop>Oxford</cop><pub>Wiley-Blackwell</pub><pmid>23452115</pmid><doi>10.1111/j.1464-410X.2013.11799.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Androgens Biological and medical sciences Biopsy, Needle Disease Progression Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Middle Aged Multivariate analysis neoplasm grading Neoplasm Grading - methods Neoplasm Grading - trends Nephrology. Urinary tract diseases Prostate Prostate - pathology Prostatectomy prostatectomy (Mesh) prostatic neoplasm Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies Tumor Burden Tumors Tumors of the urinary system tumour burden Urinary tract. Prostate gland |
| title | Upgrading of Gleason score and prostate volume: a clinicopathological analysis |
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