Combined p19Arf and interferon-beta gene transfer enhances cell death of B16 melanoma in vitro and in vivo

Approximately 90% of melanomas retain wild-type p53, a characteristic that may help shape the development of novel treatment strategies. Here, we employed an adenoviral vector where transgene expression is controlled by p53 to deliver the p19 alternate reading frame (Arf) and interferon-β (IFNβ) com...

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Veröffentlicht in:	Cancer gene therapy 2013-05, Vol.20 (5), p.317-325
Hauptverfasser:	Merkel, C A, Medrano, R F V, Barauna, V G, Strauss, B E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1813/1634 692/700/565/201 Analysis Animal models Animals Annexin V Apoptosis Apoptosis - genetics Biomedical and Life Sciences Biomedicine Caspase-3 Cell death Cell Death - genetics Cell Line, Tumor Cell survival Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Disease Models, Animal Expression vectors Female Gene Expression Gene Therapy Genetic transformation Interferon-beta - biosynthesis Interferon-beta - genetics Interferon-beta - metabolism Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL original-article p53 Protein RNA-directed DNA polymerase Transcription Transduction, Genetic Tumors β-Interferon
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