Selective Inhibition of PDE4 in Wistar Rats Can Lead to Dilatation in Testis, Efferent Ducts, and Epididymis and Subsequent Formation of Sperm Granulomas

Testicular tubular dilatation and degeneration and epididymal sperm granulomas were frequently seen in 4-week toxicity studies using different phosphodiesterase-4 (PDE4) inhibitors in Wistar rats, including the prototypic PDE4 inhibitor BYK169171. To investigate the pathogenesis of testicular and ep...

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Veröffentlicht in:	Toxicologic pathology 2013-06, Vol.41 (4), p.615-627
Hauptverfasser:	Heuser, Anke, Mecklenburg, Lars, Ockert, Deborah, Kohler, Manfred, Kemkowski, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight - drug effects Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Dilatation, Pathologic - chemically induced Dilatation, Pathologic - pathology Epididymis - drug effects Epididymis - enzymology Epididymis - pathology Genital Diseases, Male - chemically induced Genital Diseases, Male - enzymology Genital Diseases, Male - pathology Granuloma - chemically induced Granuloma - enzymology Granuloma - pathology Histocytochemistry Male Medical sciences Organ Size - drug effects Phosphodiesterase 4 Inhibitors - toxicity Rats Rats, Wistar Testis - drug effects Testis - enzymology Testis - pathology Toxicology
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