Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

Lentiviral vectors are widely used for the stable expression of genes and small hairpin RNA (shRNA)-mediated knockdown and are currently under development for clinical use in gene therapy. Pseudotyping of the vectors with VSV-G allows them to infect a wide range of cell types. However, myeloid cells...

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Veröffentlicht in:	Gene therapy 2013-05, Vol.20 (5), p.514-520
Hauptverfasser:	Bobadilla, S, Sunseri, N, Landau, N R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/1647/2300/1514 631/250/2504/133/2505 631/378/2619/1849 Analysis Biomedical and Life Sciences Biomedicine Cell Biology Copy number Dendritic cells Dendritic Cells - cytology Expression vectors Gag protein Gene Expression Gene Therapy Genetic Therapy Genetic Vectors HIV HIV-1 - genetics HIV-2 - genetics Human Genetics Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lentivirus Lentivirus - genetics Macrophages mRNA Myeloid cells Myeloid Cells - cytology Myeloid Cells - metabolism Nanotechnology original-article Packaging Proteins RNA, Small Interfering Transduction Transduction, Genetic Viral Regulatory and Accessory Proteins - genetics Virions Viruses
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