Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia

Studies showed elevated cell-free hemoglobin (Hb) in preeclampsia (PE), and Hb reacts with nitric oxide (NO), decreasing its bioavailability. Haptoglobin (Hp) is a polymorphic protein (Hp1-1, Hp2-1 and Hp2-2) that binds Hb to form a complex that is removed from circulation, thus preventing Hb-driven...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of human hypertension 2013-06, Vol.27 (6), p.349-354
Hauptverfasser:	Sertório, J T, Lacchini, R, Amaral, L M, Palei, A C T, Cavalli, R C, Sandrim, V C, Duarte, G, Tanus-Santos, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/649 631/45/612/1221 692/699/75/243/793 Adult Analysis Bioavailability Biological Availability Chemiluminescence Epidemiology Female Gene polymorphism Genetic aspects Genotype & phenotype Haptoglobin Haptoglobins - genetics Health Administration Heme Hemoglobin Humans Medicine Medicine & Public Health Nitric oxide Nitric Oxide - metabolism Nitrites original-article Oxidative stress Phenotypes Plasma Polymorphism, Genetic Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy Public Health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!