Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats
The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on...
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| Veröffentlicht in: | Biological trace element research 2011-11, Vol.143 (2), p.1031-1043 |
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| creator | Wu, Xiang-Yang Li, Fang Xu, Wei-Dong Zhao, Jiang-Li Zhao, Ting Liang, Ling-Hong Yang, Liu-Qing |
| description | The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85–17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes. |
| doi_str_mv | 10.1007/s12011-010-8916-6 |
| format | Article |
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[Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85–17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-010-8916-6</identifier><identifier>PMID: 21161430</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Acute toxicity ; Animals ; aqueous solutions ; Bioavailability ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood ; blood glucose ; Blood Glucose - drug effects ; blood lipids ; body weight ; Cholesterol - metabolism ; Chromium ; Chromium Compounds - therapeutic use ; Deoxyribonucleic acid ; Diabetes ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; DNA ; DNA damage ; DNA Damage - drug effects ; Female ; glycemic effect ; glycogen ; Hyperglycemia ; Hypoglycemic Agents - therapeutic use ; Life Sciences ; liver ; Liver Glycogen - metabolism ; malates ; Male ; malic acid ; Nutrition ; Oncology ; Rats ; Rodents ; spectroscopy ; therapeutics ; thermodynamics ; toxicity testing ; Triglycerides - metabolism</subject><ispartof>Biological trace element research, 2011-11, Vol.143 (2), p.1031-1043</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-903a49e08b0ade166a059ece6365824d8ac59083bc7af4dc1a2fbbd48635abbc3</citedby><cites>FETCH-LOGICAL-c460t-903a49e08b0ade166a059ece6365824d8ac59083bc7af4dc1a2fbbd48635abbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-010-8916-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-010-8916-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21161430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xiang-Yang</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Xu, Wei-Dong</creatorcontrib><creatorcontrib>Zhao, Jiang-Li</creatorcontrib><creatorcontrib>Zhao, Ting</creatorcontrib><creatorcontrib>Liang, Ling-Hong</creatorcontrib><creatorcontrib>Yang, Liu-Qing</creatorcontrib><title>Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85–17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes.</description><subject>Acute toxicity</subject><subject>Animals</subject><subject>aqueous solutions</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>blood lipids</subject><subject>body weight</subject><subject>Cholesterol - metabolism</subject><subject>Chromium</subject><subject>Chromium Compounds - therapeutic use</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Female</subject><subject>glycemic effect</subject><subject>glycogen</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Life Sciences</subject><subject>liver</subject><subject>Liver Glycogen - metabolism</subject><subject>malates</subject><subject>Male</subject><subject>malic acid</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Rats</subject><subject>Rodents</subject><subject>spectroscopy</subject><subject>therapeutics</subject><subject>thermodynamics</subject><subject>toxicity testing</subject><subject>Triglycerides - metabolism</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1v1DAQhi0EotvCD-ACEadyMMzEH7GPq6VApCIkoDcky3Gcrat8LHaCuv8eVykgcYDTHOZ539HoIeQZwmsEqN4kLAGRAgJVGiWVD8gGhdAUqhIekg2gZJRrxU_IaUo3AFiVmj0mJyWiRM5gQ75txznQ6-PBx31_dH4Irti6OfwI87GYumJ3HachLMN5Xdevio-2t7MvdtNw6P1tEcZi2_fTrR1pPbaL823xNtjGz7nks53TE_Kos33yT-_nGbl6d_F194Fefnpf77aX1HEJM9XALNceVAO29SilBaG985JJoUreKuuEBsUaV9mOtw5t2TVNy5VkwjaNY2fkfO09xOn74tNshpCc73s7-mlJhqFgEoQU_L8oMiF1KVmlMvryL_RmWuKYHzFKSw5KVlWGcIVcnFKKvjOHGAYbjwbB3EkyqySTJZk7SUbmzPP74qUZfPs78ctKBsoVSHk17n38c_lfrS_WUGcnY_cxJHP1JUM8a1eSl4z9BJ0RpA4</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Wu, Xiang-Yang</creator><creator>Li, Fang</creator><creator>Xu, Wei-Dong</creator><creator>Zhao, Jiang-Li</creator><creator>Zhao, Ting</creator><creator>Liang, Ling-Hong</creator><creator>Yang, Liu-Qing</creator><general>Springer-Verlag</general><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20111101</creationdate><title>Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats</title><author>Wu, Xiang-Yang ; Li, Fang ; Xu, Wei-Dong ; Zhao, Jiang-Li ; Zhao, Ting ; Liang, Ling-Hong ; Yang, Liu-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-903a49e08b0ade166a059ece6365824d8ac59083bc7af4dc1a2fbbd48635abbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute toxicity</topic><topic>Animals</topic><topic>aqueous solutions</topic><topic>Bioavailability</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood</topic><topic>blood glucose</topic><topic>Blood Glucose - drug effects</topic><topic>blood lipids</topic><topic>body weight</topic><topic>Cholesterol - metabolism</topic><topic>Chromium</topic><topic>Chromium Compounds - therapeutic use</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>Female</topic><topic>glycemic effect</topic><topic>glycogen</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Life Sciences</topic><topic>liver</topic><topic>Liver Glycogen - metabolism</topic><topic>malates</topic><topic>Male</topic><topic>malic acid</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Rats</topic><topic>Rodents</topic><topic>spectroscopy</topic><topic>therapeutics</topic><topic>thermodynamics</topic><topic>toxicity testing</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xiang-Yang</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Xu, Wei-Dong</creatorcontrib><creatorcontrib>Zhao, Jiang-Li</creatorcontrib><creatorcontrib>Zhao, Ting</creatorcontrib><creatorcontrib>Liang, Ling-Hong</creatorcontrib><creatorcontrib>Yang, Liu-Qing</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xiang-Yang</au><au>Li, Fang</au><au>Xu, Wei-Dong</au><au>Zhao, Jiang-Li</au><au>Zhao, Ting</au><au>Liang, Ling-Hong</au><au>Yang, Liu-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>143</volume><issue>2</issue><spage>1031</spage><epage>1043</epage><pages>1031-1043</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis, thermodynamic analysis, and spectroscopy studies, the molecular formula of [Cr2(LMA)3] was inferred as Cr2(C4H4O5)3·5H2O. Daily treatment with 2.85–17.10 mg/kg body mass of [Cr2(LMA)3] in alloxan-induced diabetic rats for 2 weeks indicated that low-molecular-weight organic chromium complex [Cr2(LMA)3] had better bioavailability and more beneficial influences on the improvement of controlling blood glucose, serum lipid, and liver glycogen levels compared with CrCl3·6H2O. [Cr2(LMA)3] did not cause oxidative DNA damage under physiologically relevant conditions. Acute toxicity studies revealed no-measurable toxicity of the [Cr2(LMA)3]. Collectively, these results suggest that [Cr2(LMA)3] may represent a novel, proper chromium supplement with potential therapeutic value to control blood glucose and serum lipid in diabetes.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21161430</pmid><doi>10.1007/s12011-010-8916-6</doi><tpages>13</tpages></addata></record> |
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| subjects | Acute toxicity Animals aqueous solutions Bioavailability Biochemistry Biomedical and Life Sciences Biotechnology Blood blood glucose Blood Glucose - drug effects blood lipids body weight Cholesterol - metabolism Chromium Chromium Compounds - therapeutic use Deoxyribonucleic acid Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism DNA DNA damage DNA Damage - drug effects Female glycemic effect glycogen Hyperglycemia Hypoglycemic Agents - therapeutic use Life Sciences liver Liver Glycogen - metabolism malates Male malic acid Nutrition Oncology Rats Rodents spectroscopy therapeutics thermodynamics toxicity testing Triglycerides - metabolism |
| title | Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats |
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