Implications of HIV diversity for the HIV-1 pandemic
Summary HIV-1 genetic variability within individuals and populations plays a central role in the HIV pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and...
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| Veröffentlicht in: | The Journal of infection 2013-05, Vol.66 (5), p.391-400 |
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| container_title | The Journal of infection |
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| creator | Hemelaar, Joris |
| description | Summary HIV-1 genetic variability within individuals and populations plays a central role in the HIV pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombination during HIV reverse transcription create a genetic diversity in the host which is subject to selection pressures by the immune response and antiretroviral treatment. The global distribution of HIV genetic variants and the impact of HIV diversity on pathogenesis, transmission and clinical management are reviewed. Finally, the key role of escape mutations in the immune response to HIV is discussed as well as the major challenge which HIV-1 diversity poses to HIV vaccine development. |
| doi_str_mv | 10.1016/j.jinf.2012.10.026 |
| format | Article |
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Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombination during HIV reverse transcription create a genetic diversity in the host which is subject to selection pressures by the immune response and antiretroviral treatment. The global distribution of HIV genetic variants and the impact of HIV diversity on pathogenesis, transmission and clinical management are reviewed. Finally, the key role of escape mutations in the immune response to HIV is discussed as well as the major challenge which HIV-1 diversity poses to HIV vaccine development.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2012.10.026</identifier><identifier>PMID: 23103289</identifier><identifier>CODEN: JINFD2</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Biological and medical sciences ; CRF ; Diversity ; General aspects ; Genetic Variation ; HIV ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - pathogenicity ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. 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Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombination during HIV reverse transcription create a genetic diversity in the host which is subject to selection pressures by the immune response and antiretroviral treatment. The global distribution of HIV genetic variants and the impact of HIV diversity on pathogenesis, transmission and clinical management are reviewed. Finally, the key role of escape mutations in the immune response to HIV is discussed as well as the major challenge which HIV-1 diversity poses to HIV vaccine development.</description><subject>Biological and medical sciences</subject><subject>CRF</subject><subject>Diversity</subject><subject>General aspects</subject><subject>Genetic Variation</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - pathogenicity</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Pandemics</subject><subject>Recombinant</subject><subject>Simian immunodeficiency virus</subject><subject>Subtype</subject><subject>Vaccine</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhoMo7uzqH_AgfRG89FhV6SQTEEEW3R1Y2MOqeAvd6QTT9seY9CzMvzfNjAp7WLwk4eWpongqjL1CWCOgfNetuzD6NQFSDtZA8glboeBUkqroKVtliJdVJfgZO0-pAwDNtXzOzogjcNroFau2w64Ptp7DNKZi8sX19lvRhnsXU5gPhZ9iMf9wS1pisavH1g3BvmDPfN0n9_J0X7Cvnz99ubwub26vtpcfb0orFJ9LK_0GgTSoSmuNQqnGce6h3fBGYSOV92AlCqtIKCEqXynKbyLRgF3GvmBvj313cfq1d2k2Q0jW9X09ummfDHIhNUmO-B8oodJS6AWlI2rjlFJ03uxiGOp4MAhmEWs6s4g1i9gly2Jz0etT_30zuPZvyR-TGXhzAupk697HerQh_eMUcaokZO79kXNZ3H1w0SQb3GhdG6Kzs2mn8PgcHx6U2z6MeYH9T3dwqZv2ccwrMWgSGTB3yxdYVCIB5OM7_w1lR6ah</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Hemelaar, Joris</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20130501</creationdate><title>Implications of HIV diversity for the HIV-1 pandemic</title><author>Hemelaar, Joris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-c6f810290749991577be33f0d83b71b67ff0c615c7257554f472c72225b0c4453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biological and medical sciences</topic><topic>CRF</topic><topic>Diversity</topic><topic>General aspects</topic><topic>Genetic Variation</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - pathogenicity</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Pandemics</topic><topic>Recombinant</topic><topic>Simian immunodeficiency virus</topic><topic>Subtype</topic><topic>Vaccine</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2013-05, Vol.66 (5), p.391-400 |
| issn | 0163-4453 1532-2742 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences CRF Diversity General aspects Genetic Variation HIV HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - genetics HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious Disease Infectious diseases Medical sciences Pandemics Recombinant Simian immunodeficiency virus Subtype Vaccine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Implications of HIV diversity for the HIV-1 pandemic |
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