A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats
Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish o...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.688-692 |
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| creator | Nasu-Kawaharada, Ritsuko, Ph.D Nakamura, Akio, Ph.D Kakarla, Sunil K., Ph.D Blough, Eric R., Ph.D Kohama, Kazuhiro, M.D., Ph.D Kohama, Tomoko, M.D., Ph.D |
| description | Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. |
| doi_str_mv | 10.1016/j.nut.2012.11.017 |
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Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2012.11.017</identifier><identifier>PMID: 23466053</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Blood ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabetic mother ; Diet ; Diet, High-Fat - adverse effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Female ; Fish oil ; Fish oils ; Fish Oils - adverse effects ; Fish Oils - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glucose ; Heart ; Hyperglycemia - congenital ; Hyperglycemia - prevention & control ; Hypertriglyceridemia - complications ; Hypertriglyceridemia - congenital ; Hypertriglyceridemia - prevention & control ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - therapeutic use ; Infants ; Insulin ; Insulin signaling ; Kinases ; MAP kinase signaling ; MAP Kinase Signaling System ; Maternal Nutritional Physiological Phenomena ; Medical sciences ; Myometrium - metabolism ; Offspring ; Phosphorylation ; Prediabetic State - complications ; Prediabetic State - congenital ; Prediabetic State - metabolism ; Prediabetic State - prevention & control ; Pregnancy ; Pregnancy in Diabetics - blood ; Pregnancy in Diabetics - diet therapy ; Protein Processing, Post-Translational ; Proteins ; Proto-Oncogene Proteins c-akt - metabolism ; Rats ; Rodents ; Serine - metabolism ; Threonine - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.688-692</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-67909630bbc8c21780a341671daa17271bcd14044fa96f4df266a821aadaea3f3</citedby><cites>FETCH-LOGICAL-c565t-67909630bbc8c21780a341671daa17271bcd14044fa96f4df266a821aadaea3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1315210403?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27220539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23466053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasu-Kawaharada, Ritsuko, Ph.D</creatorcontrib><creatorcontrib>Nakamura, Akio, Ph.D</creatorcontrib><creatorcontrib>Kakarla, Sunil K., Ph.D</creatorcontrib><creatorcontrib>Blough, Eric R., Ph.D</creatorcontrib><creatorcontrib>Kohama, Kazuhiro, M.D., Ph.D</creatorcontrib><creatorcontrib>Kohama, Tomoko, M.D., Ph.D</creatorcontrib><title>A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic mother</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fish oil</subject><subject>Fish oils</subject><subject>Fish Oils - adverse effects</subject><subject>Fish Oils - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Glucose</subject><subject>Heart</subject><subject>Hyperglycemia - congenital</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hypertriglyceridemia - complications</subject><subject>Hypertriglyceridemia - congenital</subject><subject>Hypertriglyceridemia - prevention & control</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Infants</subject><subject>Insulin</subject><subject>Insulin signaling</subject><subject>Kinases</subject><subject>MAP kinase signaling</subject><subject>MAP Kinase Signaling System</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Medical sciences</subject><subject>Myometrium - metabolism</subject><subject>Offspring</subject><subject>Phosphorylation</subject><subject>Prediabetic State - complications</subject><subject>Prediabetic State - congenital</subject><subject>Prediabetic State - metabolism</subject><subject>Prediabetic State - prevention & control</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Pregnancy in Diabetics - diet therapy</subject><subject>Protein Processing, Post-Translational</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Rats</subject><subject>Rodents</subject><subject>Serine - metabolism</subject><subject>Threonine - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2LFDEQhhtR3NnVH-BFAiLspduqJJ3uIAjD4hcseFDPoSad7GS2P9akZ2H-vWlmdGEP4imQet43lXqrKF4hVAio3u2qcT9XHJBXiBVg86RYYduIErmUT4sVtFqXGqA5K85T2gEAaqWfF2dcSKWgFqsirdlAs4sj9awLbmYx2C0LI_MhbdkU-lw-sDDcxeneMUuxC2TZ-nYuo-uzsGMp3GRxGG8W1bx1bPI-3cXlYvLZkzZuDpYNU65FFmlOL4pnnvrkXp7Oi-Lnp48_rr6U198-f71aX5e2VvVcqkaDVgI2G9tajk0LJCSqBjsibHiDG9uhBCk9aeVl57lS1HIk6siR8OKiuDz65uZ_7V2azRCSdX1Po5v2yaColeaybcV_oFjnVkQDGX3zCN1N-2V-R4ojSFgM8UjZOKUUnTd5JAPFg0EwS3hmZ3J4ZgnPIJocXta8PjnvN4Pr_ir-pJWBtyeAkqXeRxptSA9cw3nGdObeHzmXp3sfXDTJBjda14Xo7Gy6KfyzjQ-P1DbHG_KDt-7g0sNvTeIGzPdly5YlQw4gldTiN5jLypI</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Nasu-Kawaharada, Ritsuko, Ph.D</creator><creator>Nakamura, Akio, Ph.D</creator><creator>Kakarla, Sunil K., Ph.D</creator><creator>Blough, Eric R., Ph.D</creator><creator>Kohama, Kazuhiro, M.D., Ph.D</creator><creator>Kohama, Tomoko, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20130401</creationdate><title>A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats</title><author>Nasu-Kawaharada, Ritsuko, Ph.D ; Nakamura, Akio, Ph.D ; Kakarla, Sunil K., Ph.D ; Blough, Eric R., Ph.D ; Kohama, Kazuhiro, M.D., Ph.D ; Kohama, Tomoko, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-67909630bbc8c21780a341671daa17271bcd14044fa96f4df266a821aadaea3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic mother</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fish oil</topic><topic>Fish oils</topic><topic>Fish Oils - adverse effects</topic><topic>Fish Oils - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Glucose</topic><topic>Heart</topic><topic>Hyperglycemia - congenital</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hypertriglyceridemia - complications</topic><topic>Hypertriglyceridemia - congenital</topic><topic>Hypertriglyceridemia - prevention & control</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Infants</topic><topic>Insulin</topic><topic>Insulin signaling</topic><topic>Kinases</topic><topic>MAP kinase signaling</topic><topic>MAP Kinase Signaling System</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Medical sciences</topic><topic>Myometrium - metabolism</topic><topic>Offspring</topic><topic>Phosphorylation</topic><topic>Prediabetic State - complications</topic><topic>Prediabetic State - congenital</topic><topic>Prediabetic State - metabolism</topic><topic>Prediabetic State - prevention & control</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - blood</topic><topic>Pregnancy in Diabetics - diet therapy</topic><topic>Protein Processing, Post-Translational</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Rats</topic><topic>Rodents</topic><topic>Serine - metabolism</topic><topic>Threonine - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasu-Kawaharada, Ritsuko, Ph.D</creatorcontrib><creatorcontrib>Nakamura, Akio, Ph.D</creatorcontrib><creatorcontrib>Kakarla, Sunil K., Ph.D</creatorcontrib><creatorcontrib>Blough, Eric R., Ph.D</creatorcontrib><creatorcontrib>Kohama, Kazuhiro, M.D., Ph.D</creatorcontrib><creatorcontrib>Kohama, Tomoko, M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasu-Kawaharada, Ritsuko, Ph.D</au><au>Nakamura, Akio, Ph.D</au><au>Kakarla, Sunil K., Ph.D</au><au>Blough, Eric R., Ph.D</au><au>Kohama, Kazuhiro, M.D., Ph.D</au><au>Kohama, Tomoko, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>29</volume><issue>4</issue><spage>688</spage><epage>692</epage><pages>688-692</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23466053</pmid><doi>10.1016/j.nut.2012.11.017</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.688-692 |
| issn | 0899-9007 1873-1244 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Animals Animals, Newborn Biological and medical sciences Blood Diabetes Diabetes. Impaired glucose tolerance Diabetic mother Diet Diet, High-Fat - adverse effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Fish oil Fish oils Fish Oils - adverse effects Fish Oils - therapeutic use Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glucose Heart Hyperglycemia - congenital Hyperglycemia - prevention & control Hypertriglyceridemia - complications Hypertriglyceridemia - congenital Hypertriglyceridemia - prevention & control Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Infants Insulin Insulin signaling Kinases MAP kinase signaling MAP Kinase Signaling System Maternal Nutritional Physiological Phenomena Medical sciences Myometrium - metabolism Offspring Phosphorylation Prediabetic State - complications Prediabetic State - congenital Prediabetic State - metabolism Prediabetic State - prevention & control Pregnancy Pregnancy in Diabetics - blood Pregnancy in Diabetics - diet therapy Protein Processing, Post-Translational Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rodents Serine - metabolism Threonine - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A09%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20maternal%20diet%20rich%20in%20fish%20oil%20may%20improve%20cardiac%20Akt-related%20signaling%20in%20the%20offspring%20of%20diabetic%20mother%20rats&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Nasu-Kawaharada,%20Ritsuko,%20Ph.D&rft.date=2013-04-01&rft.volume=29&rft.issue=4&rft.spage=688&rft.epage=692&rft.pages=688-692&rft.issn=0899-9007&rft.eissn=1873-1244&rft.coden=NUTRER&rft_id=info:doi/10.1016/j.nut.2012.11.017&rft_dat=%3Cproquest_cross%3E1356924883%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1315210403&rft_id=info:pmid/23466053&rft_els_id=S0899900712004649&rfr_iscdi=true |