Crystallization of bi-functional ligand protein complexes

Homodimerization is important in signal transduction and can play a crucial role in many other biological systems. To obtaining structural information for the design of molecules able to control the signalization pathways, the proteins involved will have to be crystallized in complex with ligands th...

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Veröffentlicht in:	Journal of structural biology 2013-06, Vol.182 (3), p.246-254
Hauptverfasser:	Antoni, Claudia, Vera, Laura, Devel, Laurent, Catalani, Maria Pia, Czarny, Bertrand, Cassar-Lajeunesse, Evelyn, Nuti, Elisa, Rossello, Armando, Dive, Vincent, Stura, Enrico Adriano
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallization Crystallography, X-Ray Dimeric ligands Dimerization Drug Design Humans Ligands Matrix Metalloproteinase 12 - chemistry Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 9 - chemistry Matrix Metalloproteinase 9 - genetics Multiprotein Complexes - chemistry Protein Binding Protein Conformation Protein Multimerization
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